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| Home > Publications database > Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study. > print |
| 001 | 129237 | ||
| 005 | 20240228143413.0 | ||
| 024 | 7 | _ | |a 10.1007/s00330-015-3928-4 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Merz, Maximilian |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study. |
| 260 | _ | _ | |a Berlin |c 2016 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1525683983_24222 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Aim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in patients with multiple myeloma (MM).We performed DCE-MRI of the lumbar spine in 131 patients with newly diagnosed MM and analysed data according to the Brix model to acquire amplitude A and exchange rate constant kep. In 61 patients a second MRI performed after therapy was evaluated to assess changes in vertebral height and identify vertebral fractures.Correlation analysis revealed significant positive association between beta2-microglobulin as well as immunoparesis with DCE-MRI parameters A and kep. Additionally, A was negatively correlated with haemoglobin levels and kep was positively correlated with LDH levels. Higher baseline kep values were associated with decreased vertebral height in a second MRI (P = 0.007) and A values were associated with new vertebral fractures in the lower lumbar spine (P = 0.03 for L4). Pre-existing lytic bone lesions or remission after therapy had no impact on the occurrence of vertebral fractures. Multivariate analysis revealed that amplitude A is an independent adverse risk factor for overall survival.DCE-MRI is a non-invasive tool with significance for systemic prognosis and vertebral complications.• Qualitative parameters from DCE-MRI are correlated with established factors of disease activity • Increased marrow microcirculation might be a risk factor for loss of vertebral height and fractures • Amplitude A is an independent predictor for shortened overall survival. |
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| 650 | _ | 7 | |a Contrast Media |2 NLM Chemicals |
| 700 | 1 | _ | |a Moehler, Thomas M |b 1 |
| 700 | 1 | _ | |a Ritsch, Judith |b 2 |
| 700 | 1 | _ | |a Bäuerle, Tobias |b 3 |
| 700 | 1 | _ | |a Zechmann, Christian M |b 4 |
| 700 | 1 | _ | |a Wagner, Barbara |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Jauch, Anna |b 6 |
| 700 | 1 | _ | |a Hose, Dirk |b 7 |
| 700 | 1 | _ | |a Kunz, Christina |0 P:(DE-He78)a9f6104e5c2c26345dcb242e6bdcb2b2 |b 8 |u dkfz |
| 700 | 1 | _ | |a Hielscher, Thomas |0 P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f |b 9 |u dkfz |
| 700 | 1 | _ | |a Laue, Hendrik |b 10 |
| 700 | 1 | _ | |a Goldschmidt, Hartmut |0 P:(DE-He78)a1aa959d47e3e026abe157a8adf24b96 |b 11 |u dkfz |
| 700 | 1 | _ | |a Delorme, Stefan |0 P:(DE-He78)3e76653311420a51a5faeb80363bd73e |b 12 |u dkfz |
| 700 | 1 | _ | |a Hillengass, Jens |0 P:(DE-He78)7ccc574e713526d2a22d7acb9b2248c5 |b 13 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1007/s00330-015-3928-4 |g Vol. 26, no. 5, p. 1404 - 1411 |0 PERI:(DE-600)1472718-3 |n 5 |p 1404 - 1411 |t European radiology |v 26 |y 2016 |x 1432-1084 |
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