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@ARTICLE{Morrissy:130199,
      author       = {A. S. Morrissy and L. Garzia and D. J. H. Shih and S.
                      Zuyderduyn and X. Huang and P. Skowron and M. Remke and F.
                      M. G. Cavalli and V. Ramaswamy and P. E. Lindsay and S.
                      Jelveh and L. K. Donovan and X. Wang and B. Luu and K. Zayne
                      and Y. Li and C. Mayoh and N. Thiessen and E. Mercier and K.
                      L. Mungall and Y. Ma and K. Tse and T. Zeng and K. Shumansky
                      and A. J. L. Roth and S. Shah and H. Farooq and N. Kijima
                      and B. L. Holgado and J. J. Y. Lee and S. Matan-Lithwick and
                      J. Liu and S. C. Mack and A. Manno and K. A. Michealraj and
                      C. Nor and J. Peacock and L. Qin and J. Reimand and A.
                      Rolider and Y. Y. Thompson and X. Wu and T. Pugh and A. Ally
                      and M. Bilenky and Y. S. N. Butterfield and R. Carlsen and
                      Y. Cheng and E. Chuah and R. D. Corbett and N. Dhalla and A.
                      He and D. Lee and H. I. Li and W. Long and M. Mayo and P.
                      Plettner and J. Q. Qian and J. E. Schein and A. Tam and T.
                      Wong and I. Birol and Y. Zhao and C. C. Faria and J.
                      Pimentel and S. Nunes and T. Shalaby and M. Grotzer and I.
                      F. Pollack and R. L. Hamilton and X.-N. Li and A. E. Bendel
                      and D. W. Fults and A. W. Walter and T. Kumabe and T.
                      Tominaga and V. P. Collins and Y.-J. Cho and C. Hoffman and
                      D. Lyden and J. H. Wisoff and J. H. Garvin and D. S. Stearns
                      and L. Massimi and U. Schüller and J. Sterba and K.
                      Zitterbart and S. Puget and O. Ayrault and S. E. Dunn and D.
                      P. C. Tirapelli and C. G. Carlotti and H. Wheeler and A. R.
                      Hallahan and W. Ingram and T. J. MacDonald and J. J. Olson
                      and E. G. Van Meir and J.-Y. Lee and K.-C. Wang and S.-K.
                      Kim and B.-K. Cho and T. Pietsch and G. Fleischhack and S.
                      Tippelt and Y. S. Ra and S. Bailey and J. C. Lindsey and S.
                      C. Clifford and C. G. Eberhart and M. K. Cooper and R. J.
                      Packer and M. Massimino and M. L. Garre and U. Bartels and
                      U. Tabori and C. E. Hawkins and P. Dirks and E. Bouffet and
                      J. T. Rutka and R. J. Wechsler-Reya and W. A. Weiss and L.
                      S. Collier and A. J. Dupuy and A. Korshunov$^*$ and D.
                      Jones$^*$ and M. Kool$^*$ and P. A. Northcott and S.
                      Pfister$^*$ and D. A. Largaespada and A. J. Mungall and R.
                      A. Moore and N. Jabado and G. D. Bader and S. J. M. Jones
                      and D. Malkin and M. A. Marra and M. D. Taylor},
      title        = {{D}ivergent clonal selection dominates medulloblastoma at
                      recurrence.},
      journal      = {Nature},
      volume       = {529},
      number       = {7586},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-05279},
      pages        = {351 - 357},
      year         = {2016},
      abstract     = {The development of targeted anti-cancer therapies through
                      the study of cancer genomes is intended to increase survival
                      rates and decrease treatment-related toxicity. We treated a
                      transposon-driven, functional genomic mouse model of
                      medulloblastoma with 'humanized' in vivo therapy
                      (microneurosurgical tumour resection followed by
                      multi-fractionated, image-guided radiotherapy). Genetic
                      events in recurrent murine medulloblastoma exhibit a very
                      poor overlap with those in matched murine diagnostic samples
                      $(<5\%).$ Whole-genome sequencing of 33 pairs of human
                      diagnostic and post-therapy medulloblastomas demonstrated
                      substantial genetic divergence of the dominant clone after
                      therapy $(<12\%$ diagnostic events were retained at
                      recurrence). In both mice and humans, the dominant clone at
                      recurrence arose through clonal selection of a pre-existing
                      minor clone present at diagnosis. Targeted therapy is
                      unlikely to be effective in the absence of the target,
                      therefore our results offer a simple, proximal, and
                      remediable explanation for the failure of prior clinical
                      trials of targeted therapy.},
      cin          = {G380 / B062},
      ddc          = {070},
      cid          = {I:(DE-He78)G380-20160331 / I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26760213},
      pmc          = {pmc:PMC4936195},
      doi          = {10.1038/nature16478},
      url          = {https://inrepo02.dkfz.de/record/130199},
}