guest ::
| Home > Publications database > Divergent clonal selection dominates medulloblastoma at recurrence. > print |
| Home > Publications database > Divergent clonal selection dominates medulloblastoma at recurrence. > print |
| 001 | 130199 | ||
| 005 | 20240228143415.0 | ||
| 024 | 7 | _ | |a 10.1038/nature16478 |2 doi |
| 024 | 7 | _ | |a pmid:26760213 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4936195 |2 pmc |
| 024 | 7 | _ | |a 0028-0836 |2 ISSN |
| 024 | 7 | _ | |a 1476-4687 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4989447 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-05279 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 070 |
| 100 | 1 | _ | |a Morrissy, A Sorana |b 0 |
| 245 | _ | _ | |a Divergent clonal selection dominates medulloblastoma at recurrence. |
| 260 | _ | _ | |a London [u.a.] |c 2016 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1522134266_24184 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Garzia, Livia |b 1 |
| 700 | 1 | _ | |a Shih, David J H |b 2 |
| 700 | 1 | _ | |a Zuyderduyn, Scott |b 3 |
| 700 | 1 | _ | |a Huang, Xi |b 4 |
| 700 | 1 | _ | |a Skowron, Patryk |b 5 |
| 700 | 1 | _ | |a Remke, Marc |b 6 |
| 700 | 1 | _ | |a Cavalli, Florence M G |b 7 |
| 700 | 1 | _ | |a Ramaswamy, Vijay |b 8 |
| 700 | 1 | _ | |a Lindsay, Patricia E |b 9 |
| 700 | 1 | _ | |a Jelveh, Salomeh |b 10 |
| 700 | 1 | _ | |a Donovan, Laura K |b 11 |
| 700 | 1 | _ | |a Wang, Xin |b 12 |
| 700 | 1 | _ | |a Luu, Betty |b 13 |
| 700 | 1 | _ | |a Zayne, Kory |b 14 |
| 700 | 1 | _ | |a Li, Yisu |b 15 |
| 700 | 1 | _ | |a Mayoh, Chelsea |b 16 |
| 700 | 1 | _ | |a Thiessen, Nina |b 17 |
| 700 | 1 | _ | |a Mercier, Eloi |b 18 |
| 700 | 1 | _ | |a Mungall, Karen L |b 19 |
| 700 | 1 | _ | |a Ma, Yusanne |b 20 |
| 700 | 1 | _ | |a Tse, Kane |b 21 |
| 700 | 1 | _ | |a Zeng, Thomas |b 22 |
| 700 | 1 | _ | |a Shumansky, Karey |b 23 |
| 700 | 1 | _ | |a Roth, Andrew J L |b 24 |
| 700 | 1 | _ | |a Shah, Sohrab |b 25 |
| 700 | 1 | _ | |a Farooq, Hamza |b 26 |
| 700 | 1 | _ | |a Kijima, Noriyuki |b 27 |
| 700 | 1 | _ | |a Holgado, Borja L |b 28 |
| 700 | 1 | _ | |a Lee, John J Y |b 29 |
| 700 | 1 | _ | |a Matan-Lithwick, Stuart |b 30 |
| 700 | 1 | _ | |a Liu, Jessica |b 31 |
| 700 | 1 | _ | |a Mack, Stephen C |b 32 |
| 700 | 1 | _ | |a Manno, Alex |b 33 |
| 700 | 1 | _ | |a Michealraj, K. A. |b 34 |
| 700 | 1 | _ | |a Nor, Carolina |b 35 |
| 700 | 1 | _ | |a Peacock, John |b 36 |
| 700 | 1 | _ | |a Qin, Lei |b 37 |
| 700 | 1 | _ | |a Reimand, Juri |b 38 |
| 700 | 1 | _ | |a Rolider, Adi |b 39 |
| 700 | 1 | _ | |a Thompson, Yuan Y |b 40 |
| 700 | 1 | _ | |a Wu, Xiaochong |b 41 |
| 700 | 1 | _ | |a Pugh, Trevor |b 42 |
| 700 | 1 | _ | |a Ally, Adrian |b 43 |
| 700 | 1 | _ | |a Bilenky, Mikhail |b 44 |
| 700 | 1 | _ | |a Butterfield, Yaron S N |b 45 |
| 700 | 1 | _ | |a Carlsen, Rebecca |b 46 |
| 700 | 1 | _ | |a Cheng, Young |b 47 |
| 700 | 1 | _ | |a Chuah, Eric |b 48 |
| 700 | 1 | _ | |a Corbett, Richard D |b 49 |
| 700 | 1 | _ | |a Dhalla, Noreen |b 50 |
| 700 | 1 | _ | |a He, An |b 51 |
| 700 | 1 | _ | |a Lee, Darlene |b 52 |
| 700 | 1 | _ | |a Li, Haiyan I |b 53 |
| 700 | 1 | _ | |a Long, William |b 54 |
| 700 | 1 | _ | |a Mayo, Michael |b 55 |
| 700 | 1 | _ | |a Plettner, Patrick |b 56 |
| 700 | 1 | _ | |a Qian, Jenny Q |b 57 |
| 700 | 1 | _ | |a Schein, Jacqueline E |b 58 |
| 700 | 1 | _ | |a Tam, Angela |b 59 |
| 700 | 1 | _ | |a Wong, Tina |b 60 |
| 700 | 1 | _ | |a Birol, Inanc |b 61 |
| 700 | 1 | _ | |a Zhao, Yongjun |b 62 |
| 700 | 1 | _ | |a Faria, Claudia C |b 63 |
| 700 | 1 | _ | |a Pimentel, José |b 64 |
| 700 | 1 | _ | |a Nunes, Sofia |b 65 |
| 700 | 1 | _ | |a Shalaby, Tarek |b 66 |
| 700 | 1 | _ | |a Grotzer, Michael |b 67 |
| 700 | 1 | _ | |a Pollack, Ian F |b 68 |
| 700 | 1 | _ | |a Hamilton, Ronald L |b 69 |
| 700 | 1 | _ | |a Li, Xiao-Nan |b 70 |
| 700 | 1 | _ | |a Bendel, Anne E |b 71 |
| 700 | 1 | _ | |a Fults, Daniel W |b 72 |
| 700 | 1 | _ | |a Walter, Andrew W |b 73 |
| 700 | 1 | _ | |a Kumabe, Toshihiro |b 74 |
| 700 | 1 | _ | |a Tominaga, Teiji |b 75 |
| 700 | 1 | _ | |a Collins, V Peter |b 76 |
| 700 | 1 | _ | |a Cho, Yoon-Jae |b 77 |
| 700 | 1 | _ | |a Hoffman, Caitlin |b 78 |
| 700 | 1 | _ | |a Lyden, David |b 79 |
| 700 | 1 | _ | |a Wisoff, Jeffrey H |b 80 |
| 700 | 1 | _ | |a Garvin, James H |b 81 |
| 700 | 1 | _ | |a Stearns, Duncan S |b 82 |
| 700 | 1 | _ | |a Massimi, Luca |b 83 |
| 700 | 1 | _ | |a Schüller, Ulrich |b 84 |
| 700 | 1 | _ | |a Sterba, Jaroslav |b 85 |
| 700 | 1 | _ | |a Zitterbart, Karel |b 86 |
| 700 | 1 | _ | |a Puget, Stephanie |b 87 |
| 700 | 1 | _ | |a Ayrault, Olivier |b 88 |
| 700 | 1 | _ | |a Dunn, Sandra E |b 89 |
| 700 | 1 | _ | |a Tirapelli, Daniela P C |b 90 |
| 700 | 1 | _ | |a Carlotti, Carlos G |b 91 |
| 700 | 1 | _ | |a Wheeler, Helen |b 92 |
| 700 | 1 | _ | |a Hallahan, Andrew R |b 93 |
| 700 | 1 | _ | |a Ingram, Wendy |b 94 |
| 700 | 1 | _ | |a MacDonald, Tobey J |b 95 |
| 700 | 1 | _ | |a Olson, Jeffrey J |b 96 |
| 700 | 1 | _ | |a Van Meir, Erwin G |b 97 |
| 700 | 1 | _ | |a Lee, Ji-Yeoun |b 98 |
| 700 | 1 | _ | |a Wang, Kyu-Chang |b 99 |
| 700 | 1 | _ | |a Kim, Seung-Ki |b 100 |
| 700 | 1 | _ | |a Cho, Byung-Kyu |b 101 |
| 700 | 1 | _ | |a Pietsch, Torsten |b 102 |
| 700 | 1 | _ | |a Fleischhack, Gudrun |b 103 |
| 700 | 1 | _ | |a Tippelt, Stephan |b 104 |
| 700 | 1 | _ | |a Ra, Young Shin |b 105 |
| 700 | 1 | _ | |a Bailey, Simon |b 106 |
| 700 | 1 | _ | |a Lindsey, Janet C |b 107 |
| 700 | 1 | _ | |a Clifford, Steven C |b 108 |
| 700 | 1 | _ | |a Eberhart, Charles G |b 109 |
| 700 | 1 | _ | |a Cooper, Michael K |b 110 |
| 700 | 1 | _ | |a Packer, Roger J |b 111 |
| 700 | 1 | _ | |a Massimino, Maura |b 112 |
| 700 | 1 | _ | |a Garre, Maria Luisa |b 113 |
| 700 | 1 | _ | |a Bartels, Ute |b 114 |
| 700 | 1 | _ | |a Tabori, Uri |b 115 |
| 700 | 1 | _ | |a Hawkins, Cynthia E |b 116 |
| 700 | 1 | _ | |a Dirks, Peter |b 117 |
| 700 | 1 | _ | |a Bouffet, Eric |b 118 |
| 700 | 1 | _ | |a Rutka, James T |b 119 |
| 700 | 1 | _ | |a Wechsler-Reya, Robert J |b 120 |
| 700 | 1 | _ | |a Weiss, William A |b 121 |
| 700 | 1 | _ | |a Collier, Lara S |b 122 |
| 700 | 1 | _ | |a Dupuy, Adam J |b 123 |
| 700 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 124 |u dkfz |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 125 |u dkfz |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 126 |u dkfz |
| 700 | 1 | _ | |a Northcott, Paul A |b 127 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 128 |u dkfz |
| 700 | 1 | _ | |a Largaespada, David A |b 129 |
| 700 | 1 | _ | |a Mungall, Andrew J |b 130 |
| 700 | 1 | _ | |a Moore, Richard A |b 131 |
| 700 | 1 | _ | |a Jabado, Nada |b 132 |
| 700 | 1 | _ | |a Bader, Gary D |b 133 |
| 700 | 1 | _ | |a Jones, Steven J M |b 134 |
| 700 | 1 | _ | |a Malkin, David |b 135 |
| 700 | 1 | _ | |a Marra, Marco A |b 136 |
| 700 | 1 | _ | |a Taylor, Michael D |b 137 |
| 773 | _ | _ | |a 10.1038/nature16478 |g Vol. 529, no. 7586, p. 351 - 357 |0 PERI:(DE-600)1413423-8 |n 7586 |p 351 - 357 |t Nature |v 529 |y 2016 |x 1476-4687 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:130199 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 124 |6 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 125 |6 P:(DE-He78)551bb92841f634070997aa168d818492 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 126 |6 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 128 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2016 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NATURE : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 30 |0 StatID:(DE-HGF)9930 |2 StatID |b NATURE : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)G380-20160331 |k G380 |l KKE Neuropathologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)G380-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|