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| 005 | 20240228143416.0 | ||
| 024 | 7 | _ | |a 10.1002/elps.201500403 |2 doi |
| 024 | 7 | _ | |a pmid:26627117 |2 pmid |
| 024 | 7 | _ | |a 0173-0835 |2 ISSN |
| 024 | 7 | _ | |a 1522-2683 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-05296 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Nachbar, Markus |b 0 |
| 245 | _ | _ | |a Ca(2+) -complex stability of GAPAGPLIVPY peptide in gas and aqueous phase, investigated by affinity capillary electrophoresis and molecular dynamics simulations and compared to mass spectrometric results. |
| 260 | _ | _ | |a Weinheim |c 2016 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1522134631_24184 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Strong, sequence-specific gas-phase bindings between proline-rich peptides and alkaline earth metal ions in nanoESI-MS experiments were reported by Lehmann et al. (Rapid Commun. Mass Spectrom. 2006, 20, 2404-2410), however its relevance for physiological-like aqueous phase is uncertain. Therefore, the complexes should also be studied in aqueous solution and the relevance of the MS method for binding studies be evaluated. A mobility shift ACE method was used for determining the binding between the small peptide GAPAGPLIVPY and various metal ions in aqueous solution. The findings were compared to the MS results and further explained using computational methods. While the MS data showed a strong alkaline earth ion binding, the ACE results showed nonsignificant binding. The proposed vacuum state complex also decomposed during a molecular dynamic simulation in aqueous solution. This study shows that the formed stable peptide-metal ion adducts in the gas phase by ESI-MS does not imply the existence of analogous adducts in the aqueous phase. Comparing peptide-metal ion interaction under the gaseous MS and aqueous ACE conditions showed huge difference in binding behavior. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Gases |2 NLM Chemicals |
| 650 | _ | 7 | |a Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Calcium |0 SY7Q814VUP |2 NLM Chemicals |
| 700 | 1 | _ | |a El Deeb, Sami |b 1 |
| 700 | 1 | _ | |a Mozafari, Mona |b 2 |
| 700 | 1 | _ | |a Alhazmi, Hassan A |b 3 |
| 700 | 1 | _ | |a Preu, Lutz |b 4 |
| 700 | 1 | _ | |a Redweik, Sabine |b 5 |
| 700 | 1 | _ | |a Lehmann, Wolf Dieter |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Wätzig, Hermann |b 7 |
| 773 | _ | _ | |a 10.1002/elps.201500403 |g Vol. 37, no. 5-6, p. 744 - 751 |0 PERI:(DE-600)1475486-1 |n 5-6 |p 744 - 751 |t Electrophoresis |v 37 |y 2016 |x 0173-0835 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:130216 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-HGF)0 |
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| 914 | 1 | _ | |y 2016 |
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