%0 Journal Article
%A Richards, David M
%A Kyewski, Bruno
%A Feuerer, Markus
%T Re-examining the Nature and Function of Self-Reactive T cells.
%J Trends in immunology
%V 37
%N 2
%@ 1471-4906
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2017-05482
%P 114 - 125
%D 2016
%X Recent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens.
%K Autoantigens (NLM Chemicals)
%K Receptors, Antigen, T-Cell (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26795134
%R 10.1016/j.it.2015.12.005
%U https://inrepo02.dkfz.de/record/130403