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000130403 0247_ $$2ISSN$$a1471-4906
000130403 0247_ $$2ISSN$$a1471-4981
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000130403 041__ $$aeng
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000130403 1001_ $$0P:(DE-HGF)0$$aRichards, David M$$b0$$eFirst author
000130403 245__ $$aRe-examining the Nature and Function of Self-Reactive T cells.
000130403 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2016
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000130403 520__ $$aRecent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens.
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000130403 650_7 $$2NLM Chemicals$$aAutoantigens
000130403 650_7 $$2NLM Chemicals$$aReceptors, Antigen, T-Cell
000130403 7001_ $$0P:(DE-He78)08a57258198dcedd8ff8ac7eef40341a$$aKyewski, Bruno$$b1$$udkfz
000130403 7001_ $$0P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f$$aFeuerer, Markus$$b2$$eLast author$$udkfz
000130403 773__ $$0PERI:(DE-600)2040190-5$$a10.1016/j.it.2015.12.005$$gVol. 37, no. 2, p. 114 - 125$$n2$$p114 - 125$$tTrends in immunology$$v37$$x1471-4906$$y2016
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