TY  - JOUR
AU  - Richards, David M
AU  - Kyewski, Bruno
AU  - Feuerer, Markus
TI  - Re-examining the Nature and Function of Self-Reactive T cells.
JO  - Trends in immunology
VL  - 37
IS  - 2
SN  - 1471-4906
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2017-05482
SP  - 114 - 125
PY  - 2016
AB  - Recent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens.
KW  - Autoantigens (NLM Chemicals)
KW  - Receptors, Antigen, T-Cell (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26795134
DO  - DOI:10.1016/j.it.2015.12.005
UR  - https://inrepo02.dkfz.de/record/130403
ER  -