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@ARTICLE{Richards:130403,
      author       = {D. M. Richards$^*$ and B. Kyewski$^*$ and M. Feuerer$^*$},
      title        = {{R}e-examining the {N}ature and {F}unction of
                      {S}elf-{R}eactive {T} cells.},
      journal      = {Trends in immunology},
      volume       = {37},
      number       = {2},
      issn         = {1471-4906},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-05482},
      pages        = {114 - 125},
      year         = {2016},
      abstract     = {Recent studies have leveraged MHC tetramer and TCR
                      sequencing approaches towards a more precise
                      characterization of the peripheral T cell repertoire,
                      providing important insight into both the contribution of
                      self-reactive T cells to the overall repertoire and their
                      function. The peripheral T cell repertoire of healthy
                      individuals contains a high frequency of diverse,
                      self-reactive T cells. Furthermore, self-reactive T cells
                      can perform essential beneficial physiological functions. We
                      review these recent findings here, and discuss their
                      implications to the current understanding of peripheral
                      tolerance and the role of self-reactive T cells in
                      autoimmune disease. We outline gaps in understanding, and
                      argue that an important step forward is to revise the
                      definition of self-reactive T cells to incorporate new
                      concepts regarding the nature and physiological functions of
                      different populations of T cells capable of recognizing
                      self-antigens.},
      keywords     = {Autoantigens (NLM Chemicals) / Receptors, Antigen, T-Cell
                      (NLM Chemicals)},
      cin          = {D100 / D090},
      ddc          = {610},
      cid          = {I:(DE-He78)D100-20160331 / I:(DE-He78)D090-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26795134},
      doi          = {10.1016/j.it.2015.12.005},
      url          = {https://inrepo02.dkfz.de/record/130403},
}