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| 001 | 130403 | ||
| 005 | 20240228143431.0 | ||
| 024 | 7 | _ | |a 10.1016/j.it.2015.12.005 |2 doi |
| 024 | 7 | _ | |a pmid:26795134 |2 pmid |
| 024 | 7 | _ | |a 1471-4906 |2 ISSN |
| 024 | 7 | _ | |a 1471-4981 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4986309 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-05482 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Richards, David M |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Re-examining the Nature and Function of Self-Reactive T cells. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2016 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521715543_2107 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Recent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens. |
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| 650 | _ | 7 | |a Autoantigens |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Antigen, T-Cell |2 NLM Chemicals |
| 700 | 1 | _ | |a Kyewski, Bruno |0 P:(DE-He78)08a57258198dcedd8ff8ac7eef40341a |b 1 |u dkfz |
| 700 | 1 | _ | |a Feuerer, Markus |0 P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f |b 2 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.it.2015.12.005 |g Vol. 37, no. 2, p. 114 - 125 |0 PERI:(DE-600)2040190-5 |n 2 |p 114 - 125 |t Trends in immunology |v 37 |y 2016 |x 1471-4906 |
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