%0 Journal Article
%A Ríos-Tamayo, Rafael
%A Lupiañez, Carmen Belén
%A Campa, Daniele
%A Hielscher, Thomas
%A Weinhold, Niels
%A Martínez-López, Joaquin
%A Jerez, Andrés
%A Landi, Stefano
%A Jamroziak, Krzysztof
%A Dumontet, Charles
%A Wątek, Marzena
%A Lesueur, Fabienne
%A Reis, Rui Manuel
%A Marques, Herlander
%A Jurczyszyn, Artur
%A Vogel, Ulla
%A Buda, Gabriele
%A García-Sanz, Ramón
%A Orciuolo, Enrico
%A Petrini, Mario
%A Vangsted, Annette J
%A Gemignani, Federica
%A Försti, Asta
%A Goldschmidt, Hartmut
%A Hemminki, Kari
%A Canzian, Federico
%A Jurado, Manuel
%A Sainz, Juan
%T A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.
%J OncoTarget
%V 7
%N 37
%@ 1949-2553
%C [S.l.]
%I Impact Journals LLC
%M DKFZ-2017-05494
%P 59029 - 59048
%D 2016
%X Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27437873
%2 pmc:PMC5312293
%R 10.18632/oncotarget.10665
%U https://inrepo02.dkfz.de/record/130415