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000130415 041__ $$aeng
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000130415 1001_ $$aRíos-Tamayo, Rafael$$b0
000130415 245__ $$aA common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.
000130415 260__ $$a[S.l.]$$bImpact Journals LLC$$c2016
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000130415 520__ $$aDiabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.
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000130415 7001_ $$aLupiañez, Carmen Belén$$b1
000130415 7001_ $$aCampa, Daniele$$b2
000130415 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b3$$udkfz
000130415 7001_ $$aWeinhold, Niels$$b4
000130415 7001_ $$aMartínez-López, Joaquin$$b5
000130415 7001_ $$aJerez, Andrés$$b6
000130415 7001_ $$aLandi, Stefano$$b7
000130415 7001_ $$aJamroziak, Krzysztof$$b8
000130415 7001_ $$aDumontet, Charles$$b9
000130415 7001_ $$aWątek, Marzena$$b10
000130415 7001_ $$aLesueur, Fabienne$$b11
000130415 7001_ $$aReis, Rui Manuel$$b12
000130415 7001_ $$aMarques, Herlander$$b13
000130415 7001_ $$aJurczyszyn, Artur$$b14
000130415 7001_ $$aVogel, Ulla$$b15
000130415 7001_ $$aBuda, Gabriele$$b16
000130415 7001_ $$aGarcía-Sanz, Ramón$$b17
000130415 7001_ $$aOrciuolo, Enrico$$b18
000130415 7001_ $$aPetrini, Mario$$b19
000130415 7001_ $$aVangsted, Annette J$$b20
000130415 7001_ $$aGemignani, Federica$$b21
000130415 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aFörsti, Asta$$b22$$udkfz
000130415 7001_ $$aGoldschmidt, Hartmut$$b23
000130415 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b24$$udkfz
000130415 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b25$$udkfz
000130415 7001_ $$aJurado, Manuel$$b26
000130415 7001_ $$aSainz, Juan$$b27
000130415 773__ $$0PERI:(DE-600)2560162-3$$a10.18632/oncotarget.10665$$gVol. 7, no. 37, p. 59029 - 59048$$n37$$p59029 - 59048$$tOncoTarget$$v7$$x1949-2553$$y2016
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