TY  - JOUR
AU  - Ríos-Tamayo, Rafael
AU  - Lupiañez, Carmen Belén
AU  - Campa, Daniele
AU  - Hielscher, Thomas
AU  - Weinhold, Niels
AU  - Martínez-López, Joaquin
AU  - Jerez, Andrés
AU  - Landi, Stefano
AU  - Jamroziak, Krzysztof
AU  - Dumontet, Charles
AU  - Wątek, Marzena
AU  - Lesueur, Fabienne
AU  - Reis, Rui Manuel
AU  - Marques, Herlander
AU  - Jurczyszyn, Artur
AU  - Vogel, Ulla
AU  - Buda, Gabriele
AU  - García-Sanz, Ramón
AU  - Orciuolo, Enrico
AU  - Petrini, Mario
AU  - Vangsted, Annette J
AU  - Gemignani, Federica
AU  - Försti, Asta
AU  - Goldschmidt, Hartmut
AU  - Hemminki, Kari
AU  - Canzian, Federico
AU  - Jurado, Manuel
AU  - Sainz, Juan
TI  - A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.
JO  - OncoTarget
VL  - 7
IS  - 37
SN  - 1949-2553
CY  - [S.l.]
PB  - Impact Journals LLC
M1  - DKFZ-2017-05494
SP  - 59029 - 59048
PY  - 2016
AB  - Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:27437873
C2  - pmc:PMC5312293
DO  - DOI:10.18632/oncotarget.10665
UR  - https://inrepo02.dkfz.de/record/130415
ER  -