% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{RosTamayo:130415,
      author       = {R. Ríos-Tamayo and C. B. Lupiañez and D. Campa and T.
                      Hielscher$^*$ and N. Weinhold and J. Martínez-López and A.
                      Jerez and S. Landi and K. Jamroziak and C. Dumontet and M.
                      Wątek and F. Lesueur and R. M. Reis and H. Marques and A.
                      Jurczyszyn and U. Vogel and G. Buda and R. García-Sanz and
                      E. Orciuolo and M. Petrini and A. J. Vangsted and F.
                      Gemignani and A. Försti$^*$ and H. Goldschmidt and K.
                      Hemminki$^*$ and F. Canzian$^*$ and M. Jurado and J. Sainz},
      title        = {{A} common variant within the {HNF}1{B} gene is associated
                      with overall survival of multiple myeloma patients: results
                      from the {IMME}n{SE} consortium and meta-analysis.},
      journal      = {OncoTarget},
      volume       = {7},
      number       = {37},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-05494},
      pages        = {59029 - 59048},
      year         = {2016},
      abstract     = {Diabetogenic single nucleotide polymorphisms (SNPs) have
                      recently been associated with multiple myeloma (MM) risk but
                      their impact on overall survival (OS) of MM patients has not
                      been analysed yet. In order to investigate the impact of 58
                      GWAS-identified variants for type 2 diabetes (T2D) on OS of
                      patients with MM, we analysed genotyping data of 936 MM
                      patients collected by the International Multiple Myeloma
                      rESEarch (IMMENSE) consortium and an independent set of 700
                      MM patients recruited by the University Clinic of
                      Heidelberg. A meta-analysis of the cox regression results of
                      the two sets showed that rs7501939 located in the HNF1B gene
                      negatively impacted OS (HRRec= 1.44, $95\%$ CI = 1.18-1.76,
                      P = 0.0001). The meta-analysis also showed a noteworthy
                      gender-specific association of the SLC30A8rs13266634 SNP
                      with OS. The presence of each additional copy of the minor
                      allele at rs13266634 was associated with poor OS in men
                      whereas no association was seen in women (HRMen-Add = 1.32,
                      $95\%$ CI 1.13-1.54, P = 0.0003). In conclusion, these data
                      suggest that the HNF1Brs7501939 SNP confers poor OS in
                      patients with MM and that a SNP in SLC30A8 affect OS in
                      men.},
      cin          = {C050 / C055 / G180},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)C055-20160331 /
                      I:(DE-He78)G180-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27437873},
      pmc          = {pmc:PMC5312293},
      doi          = {10.18632/oncotarget.10665},
      url          = {https://inrepo02.dkfz.de/record/130415},
}