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000130420 0247_ $$2doi$$a10.1093/carcin/bgw080
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000130420 0247_ $$2ISSN$$a1460-2180
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000130420 041__ $$aeng
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000130420 1001_ $$0P:(DE-HGF)0$$aRizzato, Cosmeri$$b0$$eFirst author
000130420 245__ $$aAssociation of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients.
000130420 260__ $$aOxford$$bOxford Univ. Press$$c2016
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000130420 520__ $$aGermline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10(-5)) the association between 30 genomic regions and PDAC OS. With the aim to highlight the true associations within these regions, we analyzed 44 single-nucleotide polymorphisms (SNPs) in the 30 candidate regions in 1722 PDAC patients within the PANcreatic Disease ReseArch (PANDoRA) consortium. We observed statistically significant associations for five of the selected regions. One association in the CTNNA2 gene on chromosome 2p12 [rs1567532, hazard ratio (HR) = 1.75, 95% confidence interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the minor allele] and one in the last intron of the RUNX2 gene on chromosome 6p21 (rs12209785, HR = 0.88, 95% CI 0.80-0.98, P = 0.014 for heterozygotes) are of particular relevance. These loci do not coincide with those that showed the strongest associations in the previous GWAS. In silico analysis strongly suggested a possible mechanistic link between these two SNPs and pancreatic cancer survival. Functional studies are warranted to confirm the link between these genes (or other genes mapping in those regions) and PDAC prognosis in order to understand whether these variants may have the potential to impact treatment decisions and design of clinical trials.
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000130420 650_7 $$2NLM Chemicals$$aCTNNA2 protein, human
000130420 650_7 $$2NLM Chemicals$$aCore Binding Factor Alpha 1 Subunit
000130420 650_7 $$2NLM Chemicals$$aRUNX2 protein, human
000130420 650_7 $$2NLM Chemicals$$aalpha Catenin
000130420 7001_ $$0P:(DE-HGF)0$$aCampa, Daniele$$b1
000130420 7001_ $$aTalar-Wojnarowska, Renata$$b2
000130420 7001_ $$aHalloran, Christopher$$b3
000130420 7001_ $$aKupcinskas, Juozas$$b4
000130420 7001_ $$aButturini, Giovanni$$b5
000130420 7001_ $$aMohelníková-Duchoňová, Beatrice$$b6
000130420 7001_ $$aSperti, Cosimo$$b7
000130420 7001_ $$aTjaden, Christine$$b8
000130420 7001_ $$aGhaneh, Paula$$b9
000130420 7001_ $$aHackert, Thilo$$b10
000130420 7001_ $$aFunel, Niccola$$b11
000130420 7001_ $$aGiese, Nathalia$$b12
000130420 7001_ $$aTavano, Francesca$$b13
000130420 7001_ $$aPezzilli, Raffaele$$b14
000130420 7001_ $$aPedata, Mariangela$$b15
000130420 7001_ $$aPasquali, Claudio$$b16
000130420 7001_ $$aGazouli, Maria$$b17
000130420 7001_ $$aMambrini, Andrea$$b18
000130420 7001_ $$aSouček, Pavel$$b19
000130420 7001_ $$adi Sebastiano, Pierluigi$$b20
000130420 7001_ $$aCapurso, Gabriele$$b21
000130420 7001_ $$aCantore, Maurizio$$b22
000130420 7001_ $$aOliverius, Martin$$b23
000130420 7001_ $$0P:(DE-He78)81ae96953d6149e4307057d71a190019$$aOffringa, Rienk$$b24$$udkfz
000130420 7001_ $$aMałecka-Panas, Ewa$$b25
000130420 7001_ $$aStrobel, Oliver$$b26
000130420 7001_ $$aScarpa, Aldo$$b27
000130420 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b28$$eLast author$$udkfz
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