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@ARTICLE{Rizzato:130420,
      author       = {C. Rizzato$^*$ and D. Campa$^*$ and R. Talar-Wojnarowska
                      and C. Halloran and J. Kupcinskas and G. Butturini and B.
                      Mohelníková-Duchoňová and C. Sperti and C. Tjaden and P.
                      Ghaneh and T. Hackert and N. Funel and N. Giese and F.
                      Tavano and R. Pezzilli and M. Pedata and C. Pasquali and M.
                      Gazouli and A. Mambrini and P. Souček and P. di Sebastiano
                      and G. Capurso and M. Cantore and M. Oliverius and R.
                      Offringa$^*$ and E. Małecka-Panas and O. Strobel and A.
                      Scarpa and F. Canzian$^*$},
      title        = {{A}ssociation of genetic polymorphisms with survival of
                      pancreatic ductal adenocarcinoma patients.},
      journal      = {Carcinogenesis},
      volume       = {37},
      number       = {10},
      issn         = {1460-2180},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2017-05499},
      pages        = {957 - 964},
      year         = {2016},
      abstract     = {Germline genetic variability might contribute, at least
                      partially, to the survival of pancreatic ductal
                      adenocarcinoma (PDAC) patients. Two recently performed
                      genome-wide association studies (GWAS) on PDAC overall
                      survival (OS) suggested (P < 10(-5)) the association between
                      30 genomic regions and PDAC OS. With the aim to highlight
                      the true associations within these regions, we analyzed 44
                      single-nucleotide polymorphisms (SNPs) in the 30 candidate
                      regions in 1722 PDAC patients within the PANcreatic Disease
                      ReseArch (PANDoRA) consortium. We observed statistically
                      significant associations for five of the selected regions.
                      One association in the CTNNA2 gene on chromosome 2p12
                      [rs1567532, hazard ratio (HR) = 1.75, $95\%$ confidence
                      interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the
                      minor allele] and one in the last intron of the RUNX2 gene
                      on chromosome 6p21 (rs12209785, HR = 0.88, $95\%$ CI
                      0.80-0.98, P = 0.014 for heterozygotes) are of particular
                      relevance. These loci do not coincide with those that showed
                      the strongest associations in the previous GWAS. In silico
                      analysis strongly suggested a possible mechanistic link
                      between these two SNPs and pancreatic cancer survival.
                      Functional studies are warranted to confirm the link between
                      these genes (or other genes mapping in those regions) and
                      PDAC prognosis in order to understand whether these variants
                      may have the potential to impact treatment decisions and
                      design of clinical trials.},
      keywords     = {CTNNA2 protein, human (NLM Chemicals) / Core Binding Factor
                      Alpha 1 Subunit (NLM Chemicals) / RUNX2 protein, human (NLM
                      Chemicals) / alpha Catenin (NLM Chemicals)},
      cin          = {C055 / G180},
      ddc          = {610},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)G180-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27497070},
      doi          = {10.1093/carcin/bgw080},
      url          = {https://inrepo02.dkfz.de/record/130420},
}