000130427 001__ 130427
000130427 005__ 20240228143432.0
000130427 0247_ $$2doi$$a10.1007/s00401-016-1540-6
000130427 0247_ $$2pmid$$apmid:26857854
000130427 0247_ $$2ISSN$$a0001-6322
000130427 0247_ $$2ISSN$$a1432-0533
000130427 0247_ $$2altmetric$$aaltmetric:5298659
000130427 037__ $$aDKFZ-2017-05506
000130427 041__ $$aeng
000130427 082__ $$a610
000130427 1001_ $$0P:(DE-HGF)0$$aRöhrich, Manuel$$b0$$eFirst author
000130427 245__ $$aMethylation-based classification of benign and malignant peripheral nerve sheath tumors.
000130427 260__ $$aBerlin$$bSpringer$$c2016
000130427 3367_ $$2DRIVER$$aarticle
000130427 3367_ $$2DataCite$$aOutput Types/Journal article
000130427 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1524813066_6721
000130427 3367_ $$2BibTeX$$aARTICLE
000130427 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000130427 3367_ $$00$$2EndNote$$aJournal Article
000130427 520__ $$aThe vast majority of peripheral nerve sheath tumors derive from the Schwann cell lineage and comprise diverse histological entities ranging from benign schwannomas and neurofibromas to high-grade malignant peripheral nerve sheath tumors (MPNST), each with several variants. There is increasing evidence for methylation profiling being able to delineate biologically relevant tumor groups even within the same cellular lineage. Therefore, we used DNA methylation arrays for methylome- and chromosomal profile-based characterization of 171 peripheral nerve sheath tumors. We analyzed 28 conventional high-grade MPNST, three malignant Triton tumors, six low-grade MPNST, four epithelioid MPNST, 33 neurofibromas (15 dermal, 8 intraneural, 10 plexiform), six atypical neurofibromas, 43 schwannomas (including 5 NF2 and 5 schwannomatosis associated cases), 11 cellular schwannomas, 10 melanotic schwannomas, 7 neurofibroma/schwannoma hybrid tumors, 10 nerve sheath myxomas and 10 ganglioneuromas. Schwannomas formed different epigenomic subgroups including a vestibular schwannoma subgroup. Cellular schwannomas were not distinct from conventional schwannomas. Nerve sheath myxomas and neurofibroma/schwannoma hybrid tumors were most similar to schwannomas. Dermal, intraneural and plexiform neurofibromas as well as ganglioneuromas all showed distinct methylation profiles. Atypical neurofibromas and low-grade MPNST were indistinguishable with a common methylation profile and frequent losses of CDKN2A. Epigenomic analysis finds two groups of conventional high-grade MPNST sharing a frequent loss of neurofibromin. The larger of the two groups shows an additional loss of trimethylation of histone H3 at lysine 27 (H3K27me3). The smaller one retains H3K27me3 and is found in spinal locations. Sporadic MPNST with retained neurofibromin expression did not form an epigenetic group and most cases could be reclassified as cellular schwannomas or soft tissue sarcomas. Widespread immunohistochemical loss of H3K27me3 was exclusively seen in MPNST of the main methylation cluster, which defines it as an additional useful marker for the differentiation of cellular schwannoma and MPNST.
000130427 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000130427 588__ $$aDataset connected to CrossRef, PubMed,
000130427 650_7 $$2NLM Chemicals$$aNeurofibromin 1
000130427 7001_ $$0P:(DE-HGF)0$$aKoelsche, Christian$$b1
000130427 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, Daniel$$b2$$udkfz
000130427 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b3$$udkfz
000130427 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b4$$udkfz
000130427 7001_ $$0P:(DE-HGF)0$$aKratz, Annekathrin$$b5
000130427 7001_ $$0P:(DE-He78)d1fafb009178ff7771ad96c36a2c8790$$aReuss, Jana$$b6$$udkfz
000130427 7001_ $$0P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc$$aHovestadt, Volker$$b7$$udkfz
000130427 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b8$$udkfz
000130427 7001_ $$0P:(DE-He78)7999346780553d7fab7ba69d5afdfa71$$aBewerunge-Hudler, Melanie$$b9$$udkfz
000130427 7001_ $$aBecker, Albert$$b10
000130427 7001_ $$aWeis, Joachim$$b11
000130427 7001_ $$aMawrin, Christian$$b12
000130427 7001_ $$0P:(DE-He78)3494efbbc54460b109fe9eab0595adda$$aMittelbronn, Michel$$b13$$udkfz
000130427 7001_ $$aPerry, Arie$$b14
000130427 7001_ $$aMautner, Victor-Felix$$b15
000130427 7001_ $$aMechtersheimer, Gunhild$$b16
000130427 7001_ $$aHartmann, Christian$$b17
000130427 7001_ $$aOkuducu, Ali Fuat$$b18
000130427 7001_ $$aArp, Mirko$$b19
000130427 7001_ $$aSeiz-Rosenhagen, Marcel$$b20
000130427 7001_ $$aHänggi, Daniel$$b21
000130427 7001_ $$aHeim, Stefanie$$b22
000130427 7001_ $$aPaulus, Werner$$b23
000130427 7001_ $$aSchittenhelm, Jens$$b24
000130427 7001_ $$aAhmadi, Rezvan$$b25
000130427 7001_ $$aHerold-Mende, Christel$$b26
000130427 7001_ $$aUnterberg, Andreas$$b27
000130427 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b28$$udkfz
000130427 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b29$$udkfz
000130427 7001_ $$0P:(DE-HGF)0$$aReuss, David E$$b30$$eLast author
000130427 773__ $$0PERI:(DE-600)1458410-4$$a10.1007/s00401-016-1540-6$$gVol. 131, no. 6, p. 877 - 887$$n6$$p877 - 887$$tActa neuropathologica$$v131$$x1432-0533$$y2016
000130427 909CO $$ooai:inrepo02.dkfz.de:130427$$pVDB
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d1fafb009178ff7771ad96c36a2c8790$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)551bb92841f634070997aa168d818492$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7999346780553d7fab7ba69d5afdfa71$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3494efbbc54460b109fe9eab0595adda$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b28$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$aDeutsches Krebsforschungszentrum$$b29$$kDKFZ
000130427 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b30$$kDKFZ
000130427 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000130427 9141_ $$y2016
000130427 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000130427 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bACTA NEUROPATHOL : 2015
000130427 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000130427 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000130427 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000130427 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000130427 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000130427 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000130427 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000130427 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000130427 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000130427 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000130427 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000130427 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bACTA NEUROPATHOL : 2015
000130427 9201_ $$0I:(DE-He78)E055-20160331$$kE055$$lMolekulare Radioonkologie$$x0
000130427 9201_ $$0I:(DE-He78)G380-20160331$$kG380$$lKKE Neuropathologie$$x1
000130427 9201_ $$0I:(DE-He78)B060-20160331$$kB060$$lMolekulare Genetik$$x2
000130427 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lPädiatrische Neuroonkologie$$x3
000130427 9201_ $$0I:(DE-He78)W110-20160331$$kW110$$lMicroarray Unit$$x4
000130427 9201_ $$0I:(DE-He78)L501-20160331$$kL501$$lDKTK Frankfurt$$x5
000130427 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x6
000130427 980__ $$ajournal
000130427 980__ $$aVDB
000130427 980__ $$aI:(DE-He78)E055-20160331
000130427 980__ $$aI:(DE-He78)G380-20160331
000130427 980__ $$aI:(DE-He78)B060-20160331
000130427 980__ $$aI:(DE-He78)B062-20160331
000130427 980__ $$aI:(DE-He78)W110-20160331
000130427 980__ $$aI:(DE-He78)L501-20160331
000130427 980__ $$aI:(DE-He78)L101-20160331
000130427 980__ $$aUNRESTRICTED