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000130536 0247_ $$2doi$$a10.1016/j.immuni.2016.10.028
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000130536 037__ $$aDKFZ-2017-05615
000130536 041__ $$aeng
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000130536 1001_ $$aScott-Browne, James P$$b0
000130536 245__ $$aDynamic Changes in Chromatin Accessibility Occur in CD8(+) T Cells Responding to Viral Infection.
000130536 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2016
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000130536 520__ $$aIn response to acute infection, naive CD8(+) T cells expand, differentiate into effector cells, and then contract to a long-lived pool of memory cells after pathogen clearance. During chronic infections or in tumors, CD8(+) T cells acquire an 'exhausted' phenotype. Here we present genome-wide comparisons of chromatin accessibility and gene expression from endogenous CD8(+) T cells responding to acute and chronic viral infection using ATAC-seq and RNA-seq techniques. Acquisition of effector, memory, or exhausted phenotypes was associated with stable changes in chromatin accessibility away from the naive T cell state. Regions differentially accessible between functional subsets in vivo were enriched for binding sites of transcription factors known to regulate these subsets, including E2A, BATF, IRF4, T-bet, and TCF1. Exhaustion-specific accessible regions were enriched for consensus binding sites for NFAT and Nr4a family members, indicating that chronic stimulation confers a unique accessibility profile on exhausted cells.
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000130536 650_7 $$2NLM Chemicals$$aChromatin
000130536 7001_ $$aLópez-Moyado, Isaac F$$b1
000130536 7001_ $$aTrifari, Sara$$b2
000130536 7001_ $$aWong, Victor$$b3
000130536 7001_ $$0P:(DE-He78)082dd3179733e3e716a58eb90f418a78$$aChavez, Lukas$$b4$$udkfz
000130536 7001_ $$aRao, Anjana$$b5
000130536 7001_ $$aPereira, Renata M$$b6
000130536 773__ $$0PERI:(DE-600)2001966-X$$a10.1016/j.immuni.2016.10.028$$gVol. 45, no. 6, p. 1327 - 1340$$n6$$p1327 - 1340$$tImmunity$$v45$$x1074-7613$$y2016
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000130536 9141_ $$y2016
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