% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{ScottBrowne:130536,
      author       = {J. P. Scott-Browne and I. F. López-Moyado and S. Trifari
                      and V. Wong and L. Chavez$^*$ and A. Rao and R. M. Pereira},
      title        = {{D}ynamic {C}hanges in {C}hromatin {A}ccessibility {O}ccur
                      in {CD}8(+) {T} {C}ells {R}esponding to {V}iral
                      {I}nfection.},
      journal      = {Immunity},
      volume       = {45},
      number       = {6},
      issn         = {1074-7613},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-05615},
      pages        = {1327 - 1340},
      year         = {2016},
      abstract     = {In response to acute infection, naive CD8(+) T cells
                      expand, differentiate into effector cells, and then contract
                      to a long-lived pool of memory cells after pathogen
                      clearance. During chronic infections or in tumors, CD8(+)
                      T cells acquire an 'exhausted' phenotype. Here we present
                      genome-wide comparisons of chromatin accessibility and gene
                      expression from endogenous CD8(+) T cells responding to
                      acute and chronic viral infection using ATAC-seq and RNA-seq
                      techniques. Acquisition of effector, memory, or exhausted
                      phenotypes was associated with stable changes in chromatin
                      accessibility away from the naive T cell state. Regions
                      differentially accessible between functional subsets
                      in vivo were enriched for binding sites of transcription
                      factors known to regulate these subsets, including E2A,
                      BATF, IRF4, T-bet, and TCF1. Exhaustion-specific accessible
                      regions were enriched for consensus binding sites for NFAT
                      and Nr4a family members, indicating that chronic stimulation
                      confers a unique accessibility profile on exhausted cells.},
      keywords     = {Chromatin (NLM Chemicals)},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27939672},
      pmc          = {pmc:PMC5214519},
      doi          = {10.1016/j.immuni.2016.10.028},
      url          = {https://inrepo02.dkfz.de/record/130536},
}