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| 001 | 130536 | ||
| 005 | 20240228143442.0 | ||
| 024 | 7 | _ | |a 10.1016/j.immuni.2016.10.028 |2 doi |
| 024 | 7 | _ | |a pmid:27939672 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5214519 |2 pmc |
| 024 | 7 | _ | |a 1074-7613 |2 ISSN |
| 024 | 7 | _ | |a 1097-4180 |2 ISSN |
| 024 | 7 | _ | |a altmetric:14696844 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-05615 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Scott-Browne, James P |b 0 |
| 245 | _ | _ | |a Dynamic Changes in Chromatin Accessibility Occur in CD8(+) T Cells Responding to Viral Infection. |
| 260 | _ | _ | |a [Cambridge, Mass.] |c 2016 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1522142940_24184 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a In response to acute infection, naive CD8(+) T cells expand, differentiate into effector cells, and then contract to a long-lived pool of memory cells after pathogen clearance. During chronic infections or in tumors, CD8(+) T cells acquire an 'exhausted' phenotype. Here we present genome-wide comparisons of chromatin accessibility and gene expression from endogenous CD8(+) T cells responding to acute and chronic viral infection using ATAC-seq and RNA-seq techniques. Acquisition of effector, memory, or exhausted phenotypes was associated with stable changes in chromatin accessibility away from the naive T cell state. Regions differentially accessible between functional subsets in vivo were enriched for binding sites of transcription factors known to regulate these subsets, including E2A, BATF, IRF4, T-bet, and TCF1. Exhaustion-specific accessible regions were enriched for consensus binding sites for NFAT and Nr4a family members, indicating that chronic stimulation confers a unique accessibility profile on exhausted cells. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Chromatin |2 NLM Chemicals |
| 700 | 1 | _ | |a López-Moyado, Isaac F |b 1 |
| 700 | 1 | _ | |a Trifari, Sara |b 2 |
| 700 | 1 | _ | |a Wong, Victor |b 3 |
| 700 | 1 | _ | |a Chavez, Lukas |0 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |b 4 |u dkfz |
| 700 | 1 | _ | |a Rao, Anjana |b 5 |
| 700 | 1 | _ | |a Pereira, Renata M |b 6 |
| 773 | _ | _ | |a 10.1016/j.immuni.2016.10.028 |g Vol. 45, no. 6, p. 1327 - 1340 |0 PERI:(DE-600)2001966-X |n 6 |p 1327 - 1340 |t Immunity |v 45 |y 2016 |x 1074-7613 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:130536 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |
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| 914 | 1 | _ | |y 2016 |
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