%0 Journal Article
%A Selt, Florian
%A Deiß, Alica
%A Korshunov, Andrey
%A Capper, David
%A Witt, Hendrik
%A van Tilburg, Cornelis Martinus
%A Jones, David
%A Witt, Ruth
%A Sahm, Felix
%A Reuss, David
%A Kölsche, Christian
%A Ecker, Jonas
%A Oehme, Ina
%A Hielscher, Thomas
%A von Deimling, Andreas
%A Kulozik, Andreas E
%A Pfister, Stefan
%A Witt, Olaf
%A Milde, Till
%T Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors.
%J Brain pathology
%V 26
%N 4
%@ 1015-6305
%C Oxford
%I Wiley-Blackwell
%M DKFZ-2017-05621
%P 506 - 516
%D 2016
%X The 'pediatric targeted therapy' (PTT) program aims to identify the presence and activity of druggable targets and evaluate the clinical benefit of a personalized treatment approach in relapsed or progressive tumors on an individual basis. 10 markers (HDAC2, HR23B, p-AKT, p-ERK, p-S6, p-EGFR, PDGFR-alpha/beta, p53 and BRAFV600E) were analyzed by immunohistochemistry. Pediatric patients with tumors independent of the histological diagnosis, with relapse or progression after treatment according to standard protocols were included. N = 61/145 (42
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26445087
%R 10.1111/bpa.12326
%U https://inrepo02.dkfz.de/record/130542