TY  - JOUR
AU  - Selt, Florian
AU  - Deiß, Alica
AU  - Korshunov, Andrey
AU  - Capper, David
AU  - Witt, Hendrik
AU  - van Tilburg, Cornelis Martinus
AU  - Jones, David
AU  - Witt, Ruth
AU  - Sahm, Felix
AU  - Reuss, David
AU  - Kölsche, Christian
AU  - Ecker, Jonas
AU  - Oehme, Ina
AU  - Hielscher, Thomas
AU  - von Deimling, Andreas
AU  - Kulozik, Andreas E
AU  - Pfister, Stefan
AU  - Witt, Olaf
AU  - Milde, Till
TI  - Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors.
JO  - Brain pathology
VL  - 26
IS  - 4
SN  - 1015-6305
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DKFZ-2017-05621
SP  - 506 - 516
PY  - 2016
AB  - The 'pediatric targeted therapy' (PTT) program aims to identify the presence and activity of druggable targets and evaluate the clinical benefit of a personalized treatment approach in relapsed or progressive tumors on an individual basis. 10 markers (HDAC2, HR23B, p-AKT, p-ERK, p-S6, p-EGFR, PDGFR-alpha/beta, p53 and BRAFV600E) were analyzed by immunohistochemistry. Pediatric patients with tumors independent of the histological diagnosis, with relapse or progression after treatment according to standard protocols were included. N = 61/145 (42
LB  - PUB:(DE-HGF)16
C6  - pmid:26445087
DO  - DOI:10.1111/bpa.12326
UR  - https://inrepo02.dkfz.de/record/130542
ER  -