% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sjberg:130573,
      author       = {E. Sjöberg and M. Augsten$^*$ and J. Bergh and K.
                      Jirström and A. Östman},
      title        = {{E}xpression of the chemokine {CXCL}14 in the tumour stroma
                      is an independent marker of survival in breast cancer.},
      journal      = {British journal of cancer},
      volume       = {114},
      number       = {10},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-05652},
      pages        = {1117 - 1124},
      year         = {2016},
      abstract     = {Expression of the chemokine CXCL14 has previously been
                      shown to be elevated in the tumour stroma of, for example,
                      prostate and breast cancer. Cancer-associated
                      fibroblast-derived CXCL14 enhances tumour growth in mouse
                      models of prostate and breast cancer. However, the
                      prognostic significance of compartment-specific expression
                      of CXCL14 has not been studied.CXCL14 mRNA expression was
                      analysed in a breast cancer tissue microarray (TMA) of
                      formalin-fixed, paraffin-embedded tumours by the RNAscope
                      2.0 Assay. Epithelial and stromal expression was analysed
                      separately and correlated with clinicopathological
                      characteristics and survival.CXCL14 was variably and
                      independently expressed in malignant and stromal cells of
                      breast cancer. Total and stromal expression of CXCL14 did
                      not associate with clinicopathological parameters.
                      Epithelial CXCL14 expression was significantly associated
                      with oestrogen receptor α (ERα)-positive tumours and lower
                      proliferation status. Total CXCL14 expression correlated
                      significantly with shorter breast cancer-specific and
                      recurrence-free survival. High stromal, but not epithelial,
                      CXCL14 expression was significantly associated with shorter
                      survival in univariable and multivariable analyses.
                      Moreover, the correlation between stromal CXCL14 expression
                      and survival was more prominent in ER negative, triple
                      negative and basal-like breast cancers.The identification of
                      prognostic significance of stromal CXCL14 in breast cancer
                      demonstrates novel clinical relevance of a stroma-derived
                      secreted factor and illustrates the importance of tumour
                      compartment-specific analyses. On the basis of the
                      prognostic signals from difficult-to-treat subgroups, CXCL14
                      should also be considered as a candidate drug target.},
      keywords     = {Biomarkers, Tumor (NLM Chemicals) / CXCL14 protein, human
                      (NLM Chemicals) / Chemokines, CXC (NLM Chemicals)},
      cin          = {A190},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27115465},
      pmc          = {pmc:PMC4865967},
      doi          = {10.1038/bjc.2016.104},
      url          = {https://inrepo02.dkfz.de/record/130573},
}