000130601 001__ 130601
000130601 005__ 20240228143447.0
000130601 0247_ $$2doi$$a10.1186/s13014-016-0705-8
000130601 0247_ $$2pmid$$apmid:27717378
000130601 0247_ $$2pmc$$apmc:PMC5055683
000130601 0247_ $$2altmetric$$aaltmetric:12493509
000130601 037__ $$aDKFZ-2017-05679
000130601 041__ $$aeng
000130601 082__ $$a610
000130601 1001_ $$0P:(DE-HGF)0$$aSteitz, Julian$$b0$$eFirst author
000130601 245__ $$aWorst case optimization for interfractional motion mitigation in carbon ion therapy of pancreatic cancer.
000130601 260__ $$aLondon$$bBioMed Central$$c2016
000130601 3367_ $$2DRIVER$$aarticle
000130601 3367_ $$2DataCite$$aOutput Types/Journal article
000130601 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1525699382_2163
000130601 3367_ $$2BibTeX$$aARTICLE
000130601 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000130601 3367_ $$00$$2EndNote$$aJournal Article
000130601 520__ $$aThe efficacy of radiation therapy treatments for pancreatic cancer is compromised by abdominal motion which limits the spatial accuracy for dose delivery - especially for particles. In this work we investigate the potential of worst case optimization for interfractional offline motion mitigation in carbon ion treatments of pancreatic cancer.We implement a worst case optimization algorithm that explicitly models the relative biological effectiveness of carbon ions during inverse planning. We perform a comparative treatment planning study for seven pancreatic cancer patients. Treatment plans that have been generated using worst case optimization are compared against (1) conventional intensity-modulated carbon ion therapy, (2) single field uniform dose carbon ion therapy, and (3) an ideal yet impractical scenario relying on daily re-planning. The dosimetric quality and robustness of the resulting treatment plans is evaluated using reconstructions of the daily delivered dose distributions on fractional control CTs.Idealized daily re-planning consistently gives the best dosimetric results with regard to both target coverage and organ at risk sparing. The absolute reduction of D 95 within the gross tumor volume during fractional dose reconstruction is most pronounced for conventional intensity-modulated carbon ion therapy. Single field uniform dose optimization exhibits no substantial reduction for six of seven patients and values for D 95 for worst case optimization fall in between. The treated volume (D>95 % prescription dose) outside of the gross tumor volume is reduced by a factor of two by worst case optimization compared to conventional optimization and single field uniform dose optimization. Single field uniform dose optimization comes at an increased radiation exposure of normal tissues, e.g. ≈2 Gy (RBE) in the mean dose in the kidneys compared to conventional and worst case optimization and ≈4 Gy (RBE) in D 1 in the spinal cord compared to worst case optimization.Interfractional motion substantially deteriorates dose distributions for carbon ion treatments of pancreatic cancer patients. Single field uniform dose optimization mitigates the negative influence of motion on target coverage at an increased radiation exposure of normal tissue. Worst case optimization enables an exploration of the trade-off between robust target coverage and organ at risk sparing during inverse treatment planning beyond margin concepts.
000130601 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000130601 588__ $$aDataset connected to CrossRef, PubMed,
000130601 650_7 $$2NLM Chemicals$$aIons
000130601 650_7 $$07440-44-0$$2NLM Chemicals$$aCarbon
000130601 7001_ $$aNaumann, Patrick$$b1
000130601 7001_ $$0P:(DE-He78)84f1e7432f32ce7df9064fa665afc191$$aUlrich, Silke$$b2$$udkfz
000130601 7001_ $$aHaefner, Matthias F$$b3
000130601 7001_ $$0P:(DE-He78)75d45845a04db67c5a88db1086046ef1$$aSterzing, Florian$$b4$$udkfz
000130601 7001_ $$aOelfke, Uwe$$b5
000130601 7001_ $$0P:(DE-He78)fec480a99b1869ec73688e95c2f0a43b$$aBangert, Mark$$b6$$eLast author$$udkfz
000130601 773__ $$0PERI:(DE-600)2224965-5$$a10.1186/s13014-016-0705-8$$gVol. 11, no. 1, p. 134$$n1$$p134$$tRadiation oncology$$v11$$x1748-717X$$y2016
000130601 909CO $$ooai:inrepo02.dkfz.de:130601$$pVDB
000130601 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000130601 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)84f1e7432f32ce7df9064fa665afc191$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000130601 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)75d45845a04db67c5a88db1086046ef1$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000130601 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fec480a99b1869ec73688e95c2f0a43b$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000130601 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000130601 9141_ $$y2016
000130601 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000130601 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000130601 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000130601 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000130601 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000130601 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000130601 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000130601 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000130601 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000130601 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000130601 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000130601 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000130601 9201_ $$0I:(DE-He78)E040-20160331$$kE040$$lMedizinische Physik in der Strahlentherapie$$x0
000130601 980__ $$ajournal
000130601 980__ $$aVDB
000130601 980__ $$aI:(DE-He78)E040-20160331
000130601 980__ $$aUNRESTRICTED