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@ARTICLE{Sturm:130627,
      author       = {D. Sturm$^*$ and B. A. Orr and U. Toprak$^*$ and V.
                      Hovestadt$^*$ and D. Jones$^*$ and D. Capper$^*$ and M.
                      Sill$^*$ and I. Buchhalter$^*$ and P. A. Northcott$^*$ and
                      I. Leis and M. Ryzhova and C. Koelsche$^*$ and E. Pfaff$^*$
                      and S. J. Allen and G. Balasubramanian$^*$ and B. Worst$^*$
                      and K. Pajtler$^*$ and S. Brabetz$^*$ and P. Johann$^*$ and
                      F. Sahm$^*$ and J. Reimand and A. Mackay and D. M. Carvalho
                      and M. Remke$^*$ and J. J. Phillips and A. Perry and C.
                      Cowdrey and R. Drissi and M. Fouladi and F. Giangaspero and
                      M. Łastowska and W. Grajkowska and W. Scheurlen and T.
                      Pietsch and C. Hagel and J. Gojo and D. Lötsch and W.
                      Berger and I. Slavc and C. Haberler and A. Jouvet and S.
                      Holm and S. Hofer and M. Prinz and C. Keohane and I. Fried
                      and C. Mawrin and D. Scheie and B. C. Mobley and M. J.
                      Schniederjan and M. Santi and A. M. Buccoliero and S. Dahiya
                      and C. M. Kramm and A. O. von Bueren and K. von Hoff and S.
                      Rutkowski and C. Herold-Mende$^*$ and M. C. Frühwald and T.
                      Milde$^*$ and M. Hasselblatt and P. Wesseling and J.
                      Rößler and U. Schüller$^*$ and M. Ebinger$^*$ and J.
                      Schittenhelm$^*$ and S. Frank and R. Grobholz and I. Vajtai
                      and V. Hans and R. Schneppenheim and K. Zitterbart and V. P.
                      Collins and E. Aronica and P. Varlet and S. Puget and C.
                      Dufour and J. Grill and D. Figarella-Branger and M. Wolter
                      and M. U. Schuhmann$^*$ and T. Shalaby and M. Grotzer and T.
                      van Meter and C.-M. Monoranu and J. Felsberg$^*$ and G.
                      Reifenberger$^*$ and M. Snuderl and L. A. Forrester and J.
                      Koster and R. Versteeg and R. Volckmann and P. van Sluis and
                      S. Wolf$^*$ and T. Mikkelsen and A. Gajjar and K. Aldape and
                      A. S. Moore and M. D. Taylor and C. Jones and N. Jabado and
                      M. A. Karajannis and R. Eils$^*$ and M. Schlesner$^*$ and P.
                      Lichter$^*$ and A. von Deimling$^*$ and S. Pfister$^*$ and
                      D. W. Ellison and A. Korshunov$^*$ and M. Kool$^*$},
      title        = {{N}ew {B}rain {T}umor {E}ntities {E}merge from {M}olecular
                      {C}lassification of {CNS}-{PNET}s.},
      journal      = {Cell},
      volume       = {164},
      number       = {5},
      issn         = {0092-8674},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-05705},
      pages        = {1060 - 1072},
      year         = {2016},
      abstract     = {Primitive neuroectodermal tumors of the central nervous
                      system (CNS-PNETs) are highly aggressive, poorly
                      differentiated embryonal tumors occurring predominantly in
                      young children but also affecting adolescents and adults.
                      Herein, we demonstrate that a significant proportion of
                      institutionally diagnosed CNS-PNETs display molecular
                      profiles indistinguishable from those of various other
                      well-defined CNS tumor entities, facilitating diagnosis and
                      appropriate therapy for patients with these tumors. From the
                      remaining fraction of CNS-PNETs, we identify four new CNS
                      tumor entities, each associated with a recurrent genetic
                      alteration and distinct histopathological and clinical
                      features. These new molecular entities, designated 'CNS
                      neuroblastoma with FOXR2 activation (CNS NB-FOXR2),' 'CNS
                      Ewing sarcoma family tumor with CIC alteration (CNS
                      EFT-CIC),' 'CNS high-grade neuroepithelial tumor with MN1
                      alteration (CNS HGNET-MN1),' and 'CNS high-grade
                      neuroepithelial tumor with BCOR alteration (CNS
                      HGNET-BCOR),' will enable meaningful clinical trials and the
                      development of therapeutic strategies for patients affected
                      by poorly differentiated CNS tumors.},
      keywords     = {BCOR protein, human (NLM Chemicals) / CIC protein, human
                      (NLM Chemicals) / FOXR2 protein, human (NLM Chemicals) /
                      Forkhead Transcription Factors (NLM Chemicals) / MN1
                      protein, human (NLM Chemicals) / Proto-Oncogene Proteins
                      (NLM Chemicals) / Repressor Proteins (NLM Chemicals) / Tumor
                      Suppressor Proteins (NLM Chemicals)},
      cin          = {B062 / B080 / B060 / G380 / C060 / G340 / L101 / L401 /
                      L701 / L801},
      ddc          = {570},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B080-20160331 /
                      I:(DE-He78)B060-20160331 / I:(DE-He78)G380-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)G340-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)L401-20160331 /
                      I:(DE-He78)L701-20160331 / I:(DE-He78)L801-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26919435},
      pmc          = {pmc:PMC5139621},
      doi          = {10.1016/j.cell.2016.01.015},
      url          = {https://inrepo02.dkfz.de/record/130627},
}