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@ARTICLE{Thimsen:130667,
      author       = {V. Thimsen and A. Hölsken and M. Buchfelder and J. Flitsch
                      and R. Fahlbusch and H. Stefanits and M. Losa and D.
                      Jones$^*$ and R. Buslei},
      title        = {{E}p{CAM} ({CD}326) is differentially expressed in
                      craniopharyngioma subtypes and {R}athke's cleft cysts.},
      journal      = {Scientific reports},
      volume       = {6},
      number       = {1},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-05745},
      pages        = {29731},
      year         = {2016},
      abstract     = {The epithelial cell adhesion molecule (EpCAM) is a type I
                      glycoprotein located on the surface of epithelial cells. It
                      is strongly expressed in many neoplasms and already used in
                      the diagnosis and distinction of various tumour subtypes.
                      Comparative studies about EpCAM expression in cystic sellar
                      lesions are lacking. Therefore, we analysed its distribution
                      pattern in adamantinomatous (aCP) and papillary (pCP)
                      craniopharyngiomas (CP) and Rathke's Cleft Cysts (RCC) using
                      immunohistochemistry and gene expression profiling. Whereas
                      the protein was not detectable in pCP (n = 10), all aCP
                      (n = 64) showed distinct staining patterns. The vast
                      majority of RCC (n = 10) also appeared positive, but
                      these displayed notably lower labeling scores. Additionally,
                      significantly higher mRNA levels were detectable in aCP
                      (n = 19) when compared to pCP (n = 10)
                      (p = 9.985(-8)). Furthermore, pediatric aCP cases, in
                      general, exhibited stronger EpCAM staining levels compared
                      to adult ones (p = 0.015). However, we were not able to
                      verify this result on mRNA level. In summary, our findings
                      demonstrate that EpCAM can be used as an additional
                      distinction-marker for cystic lesions of the sellar region.
                      Its unknown function in aCP and the presence of an approved
                      monoclonal bispecific trifunctional antibody for cancer
                      therapy are interesting starting points for further
                      studies.},
      cin          = {B062},
      ddc          = {000},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27431859},
      pmc          = {pmc:PMC4949472},
      doi          = {10.1038/srep29731},
      url          = {https://inrepo02.dkfz.de/record/130667},
}