% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Viski:130729,
      author       = {C. Viski and C. König$^*$ and M. Kijewska and C.
                      Mogler$^*$ and C. M. Isacke and H. Augustin$^*$},
      title        = {{E}ndosialin-{E}xpressing {P}ericytes {P}romote
                      {M}etastatic {D}issemination.},
      journal      = {Cancer research},
      volume       = {76},
      number       = {18},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2017-05807},
      pages        = {5313 - 5325},
      year         = {2016},
      abstract     = {Metastasis is a multistep process that is critically
                      dependent on the interaction of metastasizing tumor cells
                      with cells in the local microenvironment. Within this tumor
                      stroma, vessel-associated pericytes and myofibroblasts share
                      a number of traits, including the upregulated expression of
                      the transmembrane receptor endosialin (CD248). Comparative
                      experiments in wild-type and endosialin-deficient mice
                      revealed that stromal endosialin does not affect primary
                      tumor growth but strongly promotes spontaneous metastasis.
                      Mechanistically, endosialin-expressing pericytes in the
                      primary tumor facilitate distant site metastasis by
                      promoting tumor cell intravasation in a cell
                      contact-dependent manner, resulting in elevated numbers of
                      circulating tumor cells. Corresponding to these preclinical
                      experiments, in independent cohorts of primary human breast
                      cancers, upregulated endosialin expression significantly
                      correlates with increased metastasis and poorer patient
                      survival. Together, the data demonstrate a critical role for
                      endosialin-expressing primary tumor pericytes in mediating
                      metastatic dissemination and identify endosialin as a
                      promising therapeutic target in breast cancer. Cancer Res;
                      76(18); 5313-25. ©2016 AACR.},
      keywords     = {Antigens, CD (NLM Chemicals) / Antigens, Neoplasm (NLM
                      Chemicals) / CD248 protein, human (NLM Chemicals) / Neoplasm
                      Proteins (NLM Chemicals) / tumor endothelial marker 1, mouse
                      (NLM Chemicals)},
      cin          = {A190 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27635044},
      doi          = {10.1158/0008-5472.CAN-16-0932},
      url          = {https://inrepo02.dkfz.de/record/130729},
}