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000130781 0247_ $$2doi$$a10.1097/RLI.0000000000000381
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000130781 037__ $$aDKFZ-2017-05859
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000130781 1001_ $$aFreedman, Joshua N$$b0
000130781 245__ $$aT2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.
000130781 260__ $$aPhiladelphia, Pa.$$bLippincott Williams & Wilkins$$c2017
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000130781 520__ $$aThe aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy.Ten patients with primary non-small cell lung cancer were scanned at 1.5 T axially with a volumetric T2-weighted turbo spin echo sequence gated to exhalation and a volumetric T1-weighted stack-of-stars spoiled gradient echo sequence with golden angle spacing acquired in free breathing. From the latter, 20 respiratory phases were reconstructed using the recently developed 4D joint MoCo-HDTV algorithm based on the self-gating signal obtained from the k-space center. Motion vector fields describing the respiratory cycle were obtained by deformable image registration between the respiratory phases and projected onto the T2-weighted image volume. The resulting 4D-T2w volumes were verified against the 4D-T1w volumes: an edge-detection method was used to measure the diaphragm positions; the locations of anatomical landmarks delineated by a radiation oncologist were compared and normalized mutual information was calculated to evaluate volumetric image similarity.High-resolution 4D-T2w MRI was obtained. Respiratory motion was preserved on calculated 4D-T2w MRI, with median diaphragm positions being consistent with less than 6.6 mm (2 voxels) for all patients and less than 3.3 mm (1 voxel) for 9 of 10 patients. Geometrical positions were coherent between 4D-T1w and 4D-T2w MRI as Euclidean distances between all corresponding anatomical landmarks agreed to within 7.6 mm (Euclidean distance of 2 voxels) and were below 3.8 mm (Euclidean distance of 1 voxel) for 355 of 470 pairs of anatomical landmarks. Volumetric image similarity was commensurate between 4D-T1w and 4D-T2w MRI, as mean percentage differences in normalized mutual information (calculated over all respiratory phases and patients), between corresponding respiratory phases of 4D-T1w and 4D-T2w MRI and the tie-phase of 4D-T1w and 3-dimensional T2w MRI, were consistent to 0.41% ± 0.37%. Four-dimensional T2w MRI displayed tumor extent, structure, and position more clearly than corresponding 4D-T1w MRI, especially when mobile tumor sites were adjacent to organs at risk.A methodology to obtain 4D-T2w MRI that retrospectively applies the motion information from 4D-T1w MRI to 3-dimensional T2w MRI was developed and verified. Four-dimensional T2w MRI can assist clinicians in delineating mobile lesions that are difficult to define on 4D-T1w MRI, because of poor tumor-tissue contrast.
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000130781 7001_ $$aCollins, David J$$b1
000130781 7001_ $$aBainbridge, Hannah$$b2
000130781 7001_ $$0P:(DE-He78)65dc5d2a03aac87b199cba2986986d05$$aRank, Christopher$$b3$$udkfz
000130781 7001_ $$aNill, Simeon$$b4
000130781 7001_ $$0P:(DE-He78)f288a8f92f092ddb41d52b1aeb915323$$aKachelrieß, Marc$$b5$$udkfz
000130781 7001_ $$aOelfke, Uwe$$b6
000130781 7001_ $$aLeach, Martin O$$b7
000130781 7001_ $$aWetscherek, Andreas$$b8
000130781 773__ $$0PERI:(DE-600)2041543-6$$a10.1097/RLI.0000000000000381$$gVol. 52, no. 10, p. 563 - 573$$n10$$p563 - 573$$tInvestigative radiology$$v52$$x0020-9996$$y2017
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