%0 Journal Article
%A Weber, Marc-Andre
%A Nagel, Armin
%A Marschar, Anja
%A Glemser, Philip Alexander
%A Jurkat-Rott, Karin
%A Wolf, Maya B
%A Ladd, Mark
%A Schlemmer, Heinz-Peter
%A Kauczor, Hans-Ulrich
%A Lehmann-Horn, Frank
%T 7-T (35)Cl and (23)Na MR Imaging for Detection of Mutation-dependent Alterations in Muscular Edema and Fat Fraction with Sodium and Chloride Concentrations in Muscular Periodic Paralyses.
%J Radiology
%V 280
%N 3
%@ 1527-1315
%C Oak Brook, Ill.
%I Soc.
%M DKFZ-2017-05907
%P 848 - 859
%D 2016
%X Purpose To determine whether altered sodium (Na(+)) and chloride (Cl(-)) homeostasis can be visualized in periodic paralyses by using 7-T sodium 23 ((23)Na) and chlorine 35 ((35)Cl) magnetic resonance (MR) imaging. Materials and Methods Institutional review board approval and informed consent of all participants were obtained. (23)Na (repetition time msec/echo time msec, 160/0.35) and (35)Cl (40/0.6) MR imaging of both lower legs was performed with a 7-T whole-body system in patients with genetically confirmed hypokalemic periodic paralysis (Cav1.1-R1239H mutation, n = 5; Cav1.1-R528H mutation, n = 8) and Andersen-Tawil syndrome (n = 3) and in 16 healthy volunteers. Additionally, each participant underwent 3-T proton MR imaging on the same day by using T1-weighted, short-tau inversion-recovery, and Dixon-type sequences. Muscle edema was assessed on short-tau inversion-recovery images, fatty degeneration was assessed on T1-weighted images, and muscular fat fraction was quantified with Dixon-type imaging. Na(+) and Cl(-) were quantified in the soleus muscle by using three phantoms that contained 10-, 20-, and 30-mmol/L NaCl solution and 5
%K Sodium Isotopes (NLM Chemicals)
%K Chlorine (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27082780
%R 10.1148/radiol.2016151617
%U https://inrepo02.dkfz.de/record/130829