TY  - JOUR
AU  - Weber, Marc-Andre
AU  - Nagel, Armin
AU  - Marschar, Anja
AU  - Glemser, Philip Alexander
AU  - Jurkat-Rott, Karin
AU  - Wolf, Maya B
AU  - Ladd, Mark
AU  - Schlemmer, Heinz-Peter
AU  - Kauczor, Hans-Ulrich
AU  - Lehmann-Horn, Frank
TI  - 7-T (35)Cl and (23)Na MR Imaging for Detection of Mutation-dependent Alterations in Muscular Edema and Fat Fraction with Sodium and Chloride Concentrations in Muscular Periodic Paralyses.
JO  - Radiology
VL  - 280
IS  - 3
SN  - 1527-1315
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DKFZ-2017-05907
SP  - 848 - 859
PY  - 2016
AB  - Purpose To determine whether altered sodium (Na(+)) and chloride (Cl(-)) homeostasis can be visualized in periodic paralyses by using 7-T sodium 23 ((23)Na) and chlorine 35 ((35)Cl) magnetic resonance (MR) imaging. Materials and Methods Institutional review board approval and informed consent of all participants were obtained. (23)Na (repetition time msec/echo time msec, 160/0.35) and (35)Cl (40/0.6) MR imaging of both lower legs was performed with a 7-T whole-body system in patients with genetically confirmed hypokalemic periodic paralysis (Cav1.1-R1239H mutation, n = 5; Cav1.1-R528H mutation, n = 8) and Andersen-Tawil syndrome (n = 3) and in 16 healthy volunteers. Additionally, each participant underwent 3-T proton MR imaging on the same day by using T1-weighted, short-tau inversion-recovery, and Dixon-type sequences. Muscle edema was assessed on short-tau inversion-recovery images, fatty degeneration was assessed on T1-weighted images, and muscular fat fraction was quantified with Dixon-type imaging. Na(+) and Cl(-) were quantified in the soleus muscle by using three phantoms that contained 10-, 20-, and 30-mmol/L NaCl solution and 5
KW  - Sodium Isotopes (NLM Chemicals)
KW  - Chlorine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27082780
DO  - DOI:10.1148/radiol.2016151617
UR  - https://inrepo02.dkfz.de/record/130829
ER  -