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| 024 | 7 | _ | |a 10.1148/radiol.2016151617 |2 doi |
| 024 | 7 | _ | |a pmid:27082780 |2 pmid |
| 024 | 7 | _ | |a 0033-8419 |2 ISSN |
| 024 | 7 | _ | |a 1527-1315 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-05907 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Weber, Marc-Andre |0 P:(DE-He78)5d10a98475a036b2a1ad3c2316d4b3ab |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a 7-T (35)Cl and (23)Na MR Imaging for Detection of Mutation-dependent Alterations in Muscular Edema and Fat Fraction with Sodium and Chloride Concentrations in Muscular Periodic Paralyses. |
| 260 | _ | _ | |a Oak Brook, Ill. |c 2016 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1525763075_9511 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Purpose To determine whether altered sodium (Na(+)) and chloride (Cl(-)) homeostasis can be visualized in periodic paralyses by using 7-T sodium 23 ((23)Na) and chlorine 35 ((35)Cl) magnetic resonance (MR) imaging. Materials and Methods Institutional review board approval and informed consent of all participants were obtained. (23)Na (repetition time msec/echo time msec, 160/0.35) and (35)Cl (40/0.6) MR imaging of both lower legs was performed with a 7-T whole-body system in patients with genetically confirmed hypokalemic periodic paralysis (Cav1.1-R1239H mutation, n = 5; Cav1.1-R528H mutation, n = 8) and Andersen-Tawil syndrome (n = 3) and in 16 healthy volunteers. Additionally, each participant underwent 3-T proton MR imaging on the same day by using T1-weighted, short-tau inversion-recovery, and Dixon-type sequences. Muscle edema was assessed on short-tau inversion-recovery images, fatty degeneration was assessed on T1-weighted images, and muscular fat fraction was quantified with Dixon-type imaging. Na(+) and Cl(-) were quantified in the soleus muscle by using three phantoms that contained 10-, 20-, and 30-mmol/L NaCl solution and 5% agarose gel as a reference. Parametric data for all subpopulations were tested by using one-way analysis of variance with the Dunnett test, and correlations were assessed with the Spearman rank correlation coefficient. Results Median muscular (23)Na concentration was higher in patients with Cav1.1-R1239H (34.7 mmol/L, P < .001), Cav1.1-R528H (32.0 mmol/L, P < .001), and Kir2.1 (24.3 mmol/L, P = .035) mutations than in healthy volunteers (19.9 mmol/L). Median muscular normalized (35)Cl signal intensity was higher in patients with Cav1.1-R1239H (27.6, P < .001) and Cav1.1-R528H (23.6, P < .001) than in healthy volunteers (12.6), but not in patients with the Kir2.1 mutation (14.3, P = .517). When compared with volunteers, patients with Cav1.1-R1239H and Cav1.1-R528H showed increased muscular edema (P < .001 and P = .003, respectively) and muscle fat fraction (P < .001 and P = .017, respectively). Conclusion With 7-T MR imaging, changes of Na(+) and Cl(-) homeostasis can be visualized in periodic paralyses and are most pronounced in the severe phenotype Cav1.1-R1239H, with up to daily paralytic episodes. (©) RSNA, 2016 An earlier incorrect version of this article appeared online. This article was corrected on April 18, 2016. |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
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| 650 | _ | 7 | |a Sodium Isotopes |2 NLM Chemicals |
| 650 | _ | 7 | |a Chlorine |0 4R7X1O2820 |2 NLM Chemicals |
| 700 | 1 | _ | |a Nagel, Armin |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 1 |u dkfz |
| 700 | 1 | _ | |a Marschar, Anja |0 P:(DE-He78)c6bc8de11c5017573e6c2dd76481a259 |b 2 |u dkfz |
| 700 | 1 | _ | |a Glemser, Philip Alexander |0 P:(DE-He78)ec15551e1bf57c41065d3502b66b1fe7 |b 3 |u dkfz |
| 700 | 1 | _ | |a Jurkat-Rott, Karin |b 4 |
| 700 | 1 | _ | |a Wolf, Maya B |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Ladd, Mark |0 P:(DE-He78)022611a2317e4de40fd912e0a72293a8 |b 6 |u dkfz |
| 700 | 1 | _ | |a Schlemmer, Heinz-Peter |0 P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec |b 7 |u dkfz |
| 700 | 1 | _ | |a Kauczor, Hans-Ulrich |b 8 |
| 700 | 1 | _ | |a Lehmann-Horn, Frank |b 9 |
| 773 | _ | _ | |a 10.1148/radiol.2016151617 |g Vol. 280, no. 3, p. 848 - 859 |0 PERI:(DE-600)2010588-5 |n 3 |p 848 - 859 |t Radiology |v 280 |y 2016 |x 1527-1315 |
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