%0 Journal Article
%A Kischkel, Frank Christian
%A Meyer, Carina
%A Eich, Julia
%A Nassir, Mani
%A Mentze, Monika
%A Braicu, Ioana
%A Kopp-Schneider, Annette
%A Sehouli, Jalid
%T Prediction of clinical response to drugs in ovarian cancer using the chemotherapy resistance test (CTR-test).
%J Journal of ovarian research
%V 10
%N 1
%@ 1757-2215
%C London
%I BioMed Central
%M DKFZ-2017-05909
%P 72
%D 2017
%X In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and the corresponding clinical response of individual patients were correlated retrospectively. Results were compared to previous recorded correlations.The CTR-Test was performed on tumor samples from 52 ovarian cancer patients for specific chemotherapeutic drugs. Patients were treated with monotherapies or drug combinations. Resistances were classified as extreme (ER), medium (MR) or slight (SR) resistance in the CTR-Test. Combination treatment resistances were transformed by a scoring system into these classifications.Accurate sensitivity prediction was accomplished in 79
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29078793
%2 pmc:PMC5658930
%R 10.1186/s13048-017-0365-9
%U https://inrepo02.dkfz.de/record/130831