TY  - JOUR
AU  - Kischkel, Frank Christian
AU  - Meyer, Carina
AU  - Eich, Julia
AU  - Nassir, Mani
AU  - Mentze, Monika
AU  - Braicu, Ioana
AU  - Kopp-Schneider, Annette
AU  - Sehouli, Jalid
TI  - Prediction of clinical response to drugs in ovarian cancer using the chemotherapy resistance test (CTR-test).
JO  - Journal of ovarian research
VL  - 10
IS  - 1
SN  - 1757-2215
CY  - London
PB  - BioMed Central
M1  - DKFZ-2017-05909
SP  - 72
PY  - 2017
AB  - In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and the corresponding clinical response of individual patients were correlated retrospectively. Results were compared to previous recorded correlations.The CTR-Test was performed on tumor samples from 52 ovarian cancer patients for specific chemotherapeutic drugs. Patients were treated with monotherapies or drug combinations. Resistances were classified as extreme (ER), medium (MR) or slight (SR) resistance in the CTR-Test. Combination treatment resistances were transformed by a scoring system into these classifications.Accurate sensitivity prediction was accomplished in 79
LB  - PUB:(DE-HGF)16
C6  - pmid:29078793
C2  - pmc:PMC5658930
DO  - DOI:10.1186/s13048-017-0365-9
UR  - https://inrepo02.dkfz.de/record/130831
ER  -