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@ARTICLE{Sawall:130905,
      author       = {S. Sawall$^*$ and D. Franke and A. Kirchherr and J.
                      Beckendorf and J. Kuntz$^*$ and J. Maier$^*$ and A. Kraupner
                      and J. Backs and A. Briel and M. Kachelriess$^*$},
      title        = {{I}n {V}ivo {Q}uantification of {M}yocardial {I}nfarction
                      in {M}ice {U}sing {M}icro-{CT} and a {N}ovel {B}lood {P}ool
                      {A}gent.},
      journal      = {Contrast media $\&$ molecular imaging},
      volume       = {2017},
      issn         = {1555-4317},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2017-05981},
      pages        = {2617047},
      year         = {2017},
      note         = {2017 Oct 16;2017:2617047},
      abstract     = {We herein developed a micro-CT method using the innovative
                      contrast agent ExiTron™ MyoC 8000 to longitudinally
                      monitor cardiac processes in vivo in small animals.
                      Experiments were performed on healthy mice and mice with
                      myocardial infarction inflicted by ligation of the left
                      anterior descending artery. Time-dependent signal
                      enhancement in different tissues of healthy mice was
                      measured and various contrast agent doses were investigated
                      so as to determine the minimum required dose for imaging of
                      the myocardium. Due to its ability to be taken up by healthy
                      myocardium but not by infarct tissue, ExiTron MyoC 8000
                      enables detection of myocardial infarction even at a very
                      low dose. The signal enhancement in the myocardium of
                      infarcted mice after contrast agent injection was exploited
                      for quantification of infarct size. The values of infarct
                      size obtained from the imaging method were compared with
                      those obtained from histology and showed a significant
                      correlation (R(2) = 0.98). Thus, the developed micro-CT
                      method allows for monitoring of a variety of processes such
                      as cardiac remodeling in longitudinal studies.},
      cin          = {E020 / E025},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E025-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29114173},
      pmc          = {pmc:PMC5662822},
      doi          = {10.1155/2017/2617047},
      url          = {https://inrepo02.dkfz.de/record/130905},
}