TY  - JOUR
AU  - Wiskemann, Joachim
AU  - Schmidt, Martina
AU  - Klassen, O.
AU  - Debus, J.
AU  - Ulrich, C. M.
AU  - Potthoff, K.
AU  - Steindorf, Karen
TI  - Effects of 12-week resistance training during radiotherapy in breast cancer patients.
JO  - Scandinavian journal of medicine & science in sports
VL  - 27
IS  - 11
SN  - 0905-7188
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DKFZ-2017-05999
SP  - 1500 - 1510
PY  - 2017
AB  - Exercise is considered to be an effective supportive treatment approach in breast cancer (BC) patients. We conducted a randomized controlled trial to assess the efficacy of a 12-week PRT during radiotherapy. Strength performance was assessed by maximal isokinetic peak torque (MIPT) in two different angular velocities (60°/s and 180°/s) and maximal voluntary isometric contraction for shoulder external and internal rotation, as well as for knee extension and flexion were assessed pre- and post-intervention in 146 patients randomized to PRT or a control group. Statistical analyses were based on analysis of covariance models for the individual changes from baseline to week 13. Intention-to-treat analyses showed significant between-group differences favoring the exercise group (EX) for MIPT in knee flexion and shoulder internal and external rotation (P < 0.05). Subgroup analyses showed borderline significant differences with regard to pretreatment history, revealing that pretreated chemotherapy patients tend to benefit more from PRT than patients without chemotherapy (P = 0.06). Strength gain at the operated arm was significantly higher than at the non-operated arm in EX. PRT was efficacious in increasing upper and lower limb strength in BC patients undergoing adjuvant radiotherapy. Patients with restrictions due to breast cancer-related surgery and pretreated with chemotherapy might benefit the most.
LB  - PUB:(DE-HGF)16
C6  - pmid:27704628
DO  - DOI:10.1111/sms.12777
UR  - https://inrepo02.dkfz.de/record/130923
ER  -