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@ARTICLE{Wiskemann:130923,
      author       = {J. Wiskemann$^*$ and M. Schmidt$^*$ and O. Klassen$^*$ and
                      J. Debus and C. M. Ulrich and K. Potthoff and K.
                      Steindorf$^*$},
      title        = {{E}ffects of 12-week resistance training during
                      radiotherapy in breast cancer patients.},
      journal      = {Scandinavian journal of medicine $\&$ science in sports},
      volume       = {27},
      number       = {11},
      issn         = {0905-7188},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2017-05999},
      pages        = {1500 - 1510},
      year         = {2017},
      abstract     = {Exercise is considered to be an effective supportive
                      treatment approach in breast cancer (BC) patients. We
                      conducted a randomized controlled trial to assess the
                      efficacy of a 12-week PRT during radiotherapy. Strength
                      performance was assessed by maximal isokinetic peak torque
                      (MIPT) in two different angular velocities (60°/s and
                      180°/s) and maximal voluntary isometric contraction for
                      shoulder external and internal rotation, as well as for knee
                      extension and flexion were assessed pre- and
                      post-intervention in 146 patients randomized to PRT or a
                      control group. Statistical analyses were based on analysis
                      of covariance models for the individual changes from
                      baseline to week 13. Intention-to-treat analyses showed
                      significant between-group differences favoring the exercise
                      group (EX) for MIPT in knee flexion and shoulder internal
                      and external rotation (P < 0.05). Subgroup analyses showed
                      borderline significant differences with regard to
                      pretreatment history, revealing that pretreated chemotherapy
                      patients tend to benefit more from PRT than patients without
                      chemotherapy (P = 0.06). Strength gain at the operated arm
                      was significantly higher than at the non-operated arm in EX.
                      PRT was efficacious in increasing upper and lower limb
                      strength in BC patients undergoing adjuvant radiotherapy.
                      Patients with restrictions due to breast cancer-related
                      surgery and pretreated with chemotherapy might benefit the
                      most.},
      cin          = {G210 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27704628},
      doi          = {10.1111/sms.12777},
      url          = {https://inrepo02.dkfz.de/record/130923},
}