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@ARTICLE{Wiskemann:130924,
      author       = {J. Wiskemann$^*$ and B. Herzog and R. Kuehl$^*$ and M.
                      Schmidt$^*$ and K. Steindorf$^*$ and R. Schwerdtfeger and P.
                      Dreger and M. Bohus},
      title        = {{I}mpact of {HSCT} {C}onditioning and {G}lucocorticoid
                      {D}ose on {E}xercise {A}dherence and {R}esponse.},
      journal      = {Medicine and science in sports and exercise},
      volume       = {49},
      number       = {11},
      issn         = {0195-9131},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DKFZ-2017-06000},
      pages        = {2143 - 2150},
      year         = {2017},
      abstract     = {Evidence from randomized controlled trials (RCT) that
                      exercise interventions have beneficial effects in patients
                      undergoing allogeneic hematopoietic stem cell
                      transplantation (allo-HSCT) is growing. However, intensive
                      chemotherapy conditioning and glucocorticoid (GC) treatment
                      is always part of an allo-HSCT and possibly affect exercise
                      adherence and training response. Therefore, we aimed to
                      examine whether various conditioning protocols or different
                      doses of GC treatment affect exercise adherence and/or
                      training response during the inpatient period.We analyzed
                      inpatient data from intervention groups of two large RCT in
                      allo-HSCT patients (n = 113). The intervention incorporated
                      partly supervised endurance and resistance exercise three to
                      five times per week. According to the potentially
                      interfering factors, the patients were divided into groups
                      depending on intensity of conditioning (myeloablative
                      conditioning (MAC), reduced-intensity conditioning (RIC),
                      and nonmyeloablative conditioning (NMC)) and cumulative dose
                      of GC treatment (GC low ≤9 mg·kg prednisone or GC high >9
                      mg·kg prednisone) and were compared.Median exercise
                      adherence (target value, five sessions weekly) during the
                      inpatient period was $64\%$ in MAC, $54\%$ in RIC, and
                      $63\%$ in NMC. The proportion of prematurely terminated
                      training sessions ranged from $11\%$ to $15\%.$ Tiredness
                      was the most frequent cause of exercise termination in all
                      groups. Exercise adherence, duration (min·wk) and type of
                      training was significantly associated with GC dose. With
                      regard to training response, results suggest that GC-low
                      patients tend to respond better in knee extensor muscle
                      strength.Exercise adherence during inpatient period is
                      significantly affected by dose of GC treatment but not by
                      condition regimen. However, given the reasonable adherence
                      rates also in the GC-high group, data support the
                      feasibility and importance of exercising for all allo-HSCT
                      patients during the inpatient period.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28657933},
      doi          = {10.1249/MSS.0000000000001357},
      url          = {https://inrepo02.dkfz.de/record/130924},
}