%0 Journal Article
%A Wu, Bian
%A Słabicki, Mikołaj
%A Sellner, Leopold
%A Dietrich, Sascha
%A Liu, Xiyang
%A Jethwa, Alexander
%A Hüllein, Jennifer
%A Walther, Tatjana
%A Wagner, Lena
%A Huang, Zhiqin
%A Zapatka, Marc
%A Zenz, Thorsten
%T MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.
%J British journal of haematology
%V 179
%N 3
%@ 0007-1048
%C Oxford [u.a.]
%I Wiley-Blackwell55962
%M DKFZ-2017-06004
%P 421 - 429
%D 2017
%X Mutations in the N-terminus of MED12 protein occur at high frequency in uterine leiomyomas and breast fibroepithelial tumours, and are frequently found in chronic lymphocytic leukaemia (CLL). MED12 mutations have been previously linked to aberrant Cyclin C-CDK8 kinase activity, but the exact oncogenic function in CLL is unknown. Here, we characterized MED12 mutations in CLL and identified recurrent mutations in 13 out of 188 CLL patients (6·9
%K MED12 protein, human (NLM Chemicals)
%K Mediator Complex (NLM Chemicals)
%K NOTCH1 protein, human (NLM Chemicals)
%K Receptor, Notch1 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28771672
%R 10.1111/bjh.14869
%U https://inrepo02.dkfz.de/record/130928