TY  - JOUR
AU  - Wu, Bian
AU  - Słabicki, Mikołaj
AU  - Sellner, Leopold
AU  - Dietrich, Sascha
AU  - Liu, Xiyang
AU  - Jethwa, Alexander
AU  - Hüllein, Jennifer
AU  - Walther, Tatjana
AU  - Wagner, Lena
AU  - Huang, Zhiqin
AU  - Zapatka, Marc
AU  - Zenz, Thorsten
TI  - MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.
JO  - British journal of haematology
VL  - 179
IS  - 3
SN  - 0007-1048
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell55962
M1  - DKFZ-2017-06004
SP  - 421 - 429
PY  - 2017
AB  - Mutations in the N-terminus of MED12 protein occur at high frequency in uterine leiomyomas and breast fibroepithelial tumours, and are frequently found in chronic lymphocytic leukaemia (CLL). MED12 mutations have been previously linked to aberrant Cyclin C-CDK8 kinase activity, but the exact oncogenic function in CLL is unknown. Here, we characterized MED12 mutations in CLL and identified recurrent mutations in 13 out of 188 CLL patients (6·9
KW  - MED12 protein, human (NLM Chemicals)
KW  - Mediator Complex (NLM Chemicals)
KW  - NOTCH1 protein, human (NLM Chemicals)
KW  - Receptor, Notch1 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:28771672
DO  - DOI:10.1111/bjh.14869
UR  - https://inrepo02.dkfz.de/record/130928
ER  -