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@ARTICLE{Wiskemann:130949,
      author       = {J. Wiskemann$^*$ and S. Hummler and C. Diepold$^*$ and M.
                      Keil$^*$ and U. Abel$^*$ and K. Steindorf$^*$ and P.
                      Beckhove$^*$ and C. M. Ulrich and M. Steins and M. Thomas},
      title        = {{POSITIVE} study: physical exercise program in non-operable
                      lung cancer patients undergoing palliative treatment.},
      journal      = {BMC cancer},
      volume       = {16},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2017-06025},
      pages        = {499},
      year         = {2016},
      abstract     = {Patients with advanced stage non-small cell lung cancer
                      (NSCLC) or small cell lung cancer (SCLC) often experience
                      multidimensional impairments, affecting quality of life
                      during their course of disease. In lung cancer patients with
                      operable disease, several studies have shown that exercise
                      has a positive impact on quality of life and physical
                      functioning. There is limited evidence regarding efficacy
                      for advanced lung cancer patients undergoing palliative
                      treatment. Therefore, the POSITIVE study aims to evaluate
                      the benefit of a 24-week exercise intervention during
                      palliative treatment in a randomized controlled setting.The
                      POSITIVE study is a randomized, controlled trial
                      investigating the effects of a 24-week exercise intervention
                      during palliative treatment on quality of life, physical
                      performance and immune function in advanced, non-operable
                      lung cancer patients. 250 patients will be recruited in the
                      Clinic for Thoracic Diseases in Heidelberg, enrolment begun
                      in November 2013. Main inclusion criterion is histologically
                      confirmed NSCLC (stage IIIa, IIIb, IV) or SCLC (Limited
                      Disease-SCLC, Extensive Disease-SCLC) not amenable to
                      surgery. Patients are randomized into two groups. Both
                      groups receive weekly care management phone calls (CMPCs)
                      with the goal to assess symptoms and side effects.
                      Additionally, one group receives a combined resistance and
                      endurance training (3x/week). Primary endpoints are quality
                      of life assessed by the Functional Assessment of Cancer
                      Therapy for patients with lung cancer (FACT-L, subcategory
                      Physical Well-Being) and General Fatigue measured by the
                      Multidimensional Fatigue Inventory (MFI-20). Secondary
                      endpoints are physical performance (maximal voluntary
                      isometric contraction, 6-min walk distance), psychosocial
                      (depression and anxiety) and immunological parameters and
                      overall survival.The aim of the POSITIVE trial is the
                      evaluation of effects of a 24-week structured and guided
                      exercise intervention during palliative treatment stages.
                      Analysis of various outcomes (such as quality of life,
                      physical performance, self-efficacy, psychosocial and
                      immunological parameters) will contribute to a better
                      understanding of the potential of exercise in advanced lung
                      cancer patients. In contrast to other studies with advanced
                      oncological patients the POSITIVE trial provides weekly
                      phone calls to support patients both in the intervention and
                      control group and to segregate the impact of physical
                      activity on quality of life.ClinicalTrials.gov NCT02055508
                      (Date: December 12, 2013).},
      cin          = {G210 / G040 / D015 / G808},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331 / I:(DE-He78)G040-20160331 /
                      I:(DE-He78)D015-20160331 / I:(DE-He78)G808-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27430336},
      pmc          = {pmc:PMC4949758},
      doi          = {10.1186/s12885-016-2561-1},
      url          = {https://inrepo02.dkfz.de/record/130949},
}