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000130952 1001_ $$0P:(DE-He78)44dc011368b331679dbc8d341ae41420$$aDräger, Nina$$b0$$eFirst author$$udkfz
000130952 245__ $$aBin1 directly remodels actin dynamics through its BAR domain.
000130952 260__ $$aHeidelberg$$bEMBO Press$$c2017
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000130952 520__ $$aEndocytic processes are facilitated by both curvature-generating BAR-domain proteins and the coordinated polymerization of actin filaments. Under physiological conditions, the N-BAR protein Bin1 has been shown to sense and curve membranes in a variety of cellular processes. Recent studies have identified Bin1 as a risk factor for Alzheimers disease, although its possible pathological function in neurodegeneration is currently unknown. Here, we report that Bin1 not only shapes membranes, but is also directly involved in actin binding through its BAR domain. We observed a moderate actin bundling activity by human Bin1 and describe its ability to stabilize actin filaments against depolymerization. Moreover, Bin1 is also involved in stabilizing tau-induced actin bundles, which are neuropathological hallmarks of Alzheimers disease. We also provide evidence for this effect in vivo, where we observed that downregulation of Bin1 in a Drosophila model of tauopathy significantly reduces the appearance of tau-induced actin inclusions. Together, these findings reveal the ability of Bin1 to modify actin dynamics and provide a possible mechanistic connection between Bin1 and tau-induced pathobiological changes of the actin cytoskeleton.
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000130952 7001_ $$0P:(DE-He78)8fb1154d3b554bce1ecf653af8b5ea30$$aNachman, Eliana$$b1$$udkfz
000130952 7001_ $$aWinterhoff, Moritz$$b2
000130952 7001_ $$aBrühmann, Stefan$$b3
000130952 7001_ $$0P:(DE-He78)7d71bf7e3b8407442727c915a8180b86$$aShah, Pranav$$b4$$udkfz
000130952 7001_ $$0P:(DE-He78)f10e8e85107a44f96026964428163c18$$aKatsinelos, Taxiarchis$$b5$$udkfz
000130952 7001_ $$0P:(DE-He78)4658b59d5b4e54b919fc63ab1213c78f$$aBoulant, Steeve$$b6$$udkfz
000130952 7001_ $$00000-0002-4237-9368$$aTeleman, Aurelio A$$b7
000130952 7001_ $$00000-0003-1803-9192$$aFaix, Jan$$b8
000130952 7001_ $$00000-0002-9266-6736$$aJahn, Thomas R$$b9$$eLast author
000130952 773__ $$0PERI:(DE-600)2025376-X$$a10.15252/embr.201744137$$gVol. 18, no. 11, p. 2051 - 2066$$n11$$p2051 - 2066$$tEMBO reports$$v18$$x1469-3178$$y2017
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