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000130955 1001_ $$0P:(DE-He78)33c74005e1ce56f7025c4f6be15321b3$$aMaier-Hein, Klaus$$b0$$eFirst author
000130955 245__ $$aThe challenge of mapping the human connectome based on diffusion tractography.
000130955 260__ $$aLondon$$bNature Publishing Group$$c2017
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000130955 520__ $$aTractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.
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000130955 7001_ $$00000-0002-5285-7554$$aNeher, Peter F$$b1
000130955 7001_ $$aHoude, Jean-Christophe$$b2
000130955 7001_ $$aCôté, Marc-Alexandre$$b3
000130955 7001_ $$00000-0002-3991-2774$$aGaryfallidis, Eleftherios$$b4
000130955 7001_ $$aZhong, Jidan$$b5
000130955 7001_ $$aChamberland, Maxime$$b6
000130955 7001_ $$aYeh, Fang-Cheng$$b7
000130955 7001_ $$aLin, Ying-Chia$$b8
000130955 7001_ $$aJi, Qing$$b9
000130955 7001_ $$00000-0002-1054-1201$$aReddick, Wilburn E$$b10
000130955 7001_ $$00000-0001-9679-2054$$aGlass, John O$$b11
000130955 7001_ $$aChen, David Qixiang$$b12
000130955 7001_ $$00000-0002-9398-5456$$aFeng, Yuanjing$$b13
000130955 7001_ $$aGao, Chengfeng$$b14
000130955 7001_ $$aWu, Ye$$b15
000130955 7001_ $$aMa, Jieyan$$b16
000130955 7001_ $$aRenjie, H.$$b17
000130955 7001_ $$aLi, Qiang$$b18
000130955 7001_ $$aWestin, Carl-Fredrik$$b19
000130955 7001_ $$00000-0003-2781-121X$$aDeslauriers-Gauthier, Samuel$$b20
000130955 7001_ $$aGonzález, J Omar Ocegueda$$b21
000130955 7001_ $$aPaquette, Michael$$b22
000130955 7001_ $$00000-0002-8092-2974$$aSt-Jean, Samuel$$b23
000130955 7001_ $$aGirard, Gabriel$$b24
000130955 7001_ $$00000-0002-0097-8004$$aRheault, François$$b25
000130955 7001_ $$aSidhu, Jasmeen$$b26
000130955 7001_ $$aTax, Chantal M W$$b27
000130955 7001_ $$aGuo, Fenghua$$b28
000130955 7001_ $$aMesri, Hamed Y$$b29
000130955 7001_ $$00000-0003-0316-3895$$aDávid, Szabolcs$$b30
000130955 7001_ $$00000-0003-3841-0497$$aFroeling, Martijn$$b31
000130955 7001_ $$aHeemskerk, Anneriet M$$b32
000130955 7001_ $$aLeemans, Alexander$$b33
000130955 7001_ $$aBoré, Arnaud$$b34
000130955 7001_ $$00000-0002-4391-3075$$aPinsard, Basile$$b35
000130955 7001_ $$aBedetti, Christophe$$b36
000130955 7001_ $$aDesrosiers, Matthieu$$b37
000130955 7001_ $$aBrambati, Simona$$b38
000130955 7001_ $$aDoyon, Julien$$b39
000130955 7001_ $$00000-0003-1362-6718$$aSarica, Alessia$$b40
000130955 7001_ $$aVasta, Roberta$$b41
000130955 7001_ $$00000-0002-8022-4770$$aCerasa, Antonio$$b42
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000130955 7001_ $$aYeatman, Jason$$b44
000130955 7001_ $$00000-0002-0760-8647$$aKhan, Ali R$$b45
000130955 7001_ $$aHodges, Wes$$b46
000130955 7001_ $$aAlexander, Simon$$b47
000130955 7001_ $$aRomascano, David$$b48
000130955 7001_ $$00000-0001-8557-9223$$aBarakovic, Muhamed$$b49
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000130955 7001_ $$aCetingul, H Ertan$$b54
000130955 7001_ $$aOdry, Benjamin L$$b55
000130955 7001_ $$aMailhe, Boris$$b56
000130955 7001_ $$aNadar, Mariappan S$$b57
000130955 7001_ $$00000-0003-4582-0224$$aPizzagalli, Fabrizio$$b58
000130955 7001_ $$aPrasad, Gautam$$b59
000130955 7001_ $$aVillalon-Reina, Julio E$$b60
000130955 7001_ $$aGalvis, Justin$$b61
000130955 7001_ $$aThompson, Paul M$$b62
000130955 7001_ $$aRequejo, Francisco De Santiago$$b63
000130955 7001_ $$aLaguna, Pedro Luque$$b64
000130955 7001_ $$aLacerda, Luis Miguel$$b65
000130955 7001_ $$aBarrett, Rachel$$b66
000130955 7001_ $$aDell'Acqua, Flavio$$b67
000130955 7001_ $$aCatani, Marco$$b68
000130955 7001_ $$aPetit, Laurent$$b69
000130955 7001_ $$aCaruyer, Emmanuel$$b70
000130955 7001_ $$00000-0002-4677-6678$$aDaducci, Alessandro$$b71
000130955 7001_ $$aDyrby, Tim B$$b72
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000130955 7001_ $$aStieltjes, Bram$$b75
000130955 7001_ $$aDescoteaux, Maxime$$b76
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