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@ARTICLE{MaierHein:130955,
      author       = {K. Maier-Hein$^*$ and P. F. Neher$^*$ and J.-C. Houde and
                      M.-A. Côté and E. Garyfallidis and J. Zhong and M.
                      Chamberland and F.-C. Yeh and Y.-C. Lin and Q. Ji and W. E.
                      Reddick and J. O. Glass and D. Q. Chen and Y. Feng and C.
                      Gao and Y. Wu and J. Ma and H. Renjie and Q. Li and C.-F.
                      Westin and S. Deslauriers-Gauthier and J. O. O. González
                      and M. Paquette and S. St-Jean and G. Girard and F. Rheault
                      and J. Sidhu and C. M. W. Tax and F. Guo and H. Y. Mesri and
                      S. Dávid and M. Froeling and A. M. Heemskerk and A. Leemans
                      and A. Boré and B. Pinsard and C. Bedetti and M. Desrosiers
                      and S. Brambati and J. Doyon and A. Sarica and R. Vasta and
                      A. Cerasa and A. Quattrone and J. Yeatman and A. R. Khan and
                      W. Hodges and S. Alexander and D. Romascano and M. Barakovic
                      and A. Auría and O. Esteban and A. Lemkaddem and J.-P.
                      Thiran and H. E. Cetingul and B. L. Odry and B. Mailhe and
                      M. S. Nadar and F. Pizzagalli and G. Prasad and J. E.
                      Villalon-Reina and J. Galvis and P. M. Thompson and F. D. S.
                      Requejo and P. L. Laguna and L. M. Lacerda and R. Barrett
                      and F. Dell'Acqua and M. Catani and L. Petit and E. Caruyer
                      and A. Daducci and T. B. Dyrby and T. Holland-Letz$^*$ and
                      C. C. Hilgetag and B. Stieltjes and M. Descoteaux},
      title        = {{T}he challenge of mapping the human connectome based on
                      diffusion tractography.},
      journal      = {Nature Communications},
      volume       = {8},
      number       = {1},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-06031},
      pages        = {1349},
      year         = {2017},
      abstract     = {Tractography based on non-invasive diffusion imaging is
                      central to the study of human brain connectivity. To date,
                      the approach has not been systematically validated in ground
                      truth studies. Based on a simulated human brain data set
                      with ground truth tracts, we organized an open international
                      tractography challenge, which resulted in 96 distinct
                      submissions from 20 research groups. Here, we report the
                      encouraging finding that most state-of-the-art algorithms
                      produce tractograms containing $90\%$ of the ground truth
                      bundles (to at least some extent). However, the same
                      tractograms contain many more invalid than valid bundles,
                      and half of these invalid bundles occur systematically
                      across research groups. Taken together, our results
                      demonstrate and confirm fundamental ambiguities inherent in
                      tract reconstruction based on orientation information alone,
                      which need to be considered when interpreting tractography
                      and connectivity results. Our approach provides a novel
                      framework for estimating reliability of tractography and
                      encourages innovation to address its current limitations.},
      cin          = {E132 / C060},
      ddc          = {500},
      cid          = {I:(DE-He78)E132-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29116093},
      pmc          = {pmc:PMC5677006},
      doi          = {10.1038/s41467-017-01285-x},
      url          = {https://inrepo02.dkfz.de/record/130955},
}