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@ARTICLE{Liebers:131060,
      author       = {N. Liebers and T. Holland-Letz$^*$ and M. Welschof and A.
                      Høgset and D. Jäger and M. A. E. Arndt and J. Krauss},
      title        = {{H}ighly efficient destruction of squamous carcinoma cells
                      of the head and neck by photochemical internalization of
                      {R}anpirnase.},
      journal      = {Journal of experimental therapeutics $\&$ oncology},
      volume       = {12},
      number       = {2},
      issn         = {1359-4117},
      address      = {Philadelphia, Pa.},
      publisher    = {Old City Publ.},
      reportid     = {DKFZ-2017-06127},
      pages        = {113-120},
      year         = {2017},
      abstract     = {Photochemical Internalization is a novel drug delivery
                      technology for cancer treatment based on the principle of
                      Photodynamic Treatment. Using a photosensitizer that locates
                      in endocytic vesicles membranes of tumor cells,
                      Photochemical internalization enables cytosolic release of
                      endocytosed antitumor agents in a site-specific manner. The
                      purpose of the present in-vitro study was to explore whether
                      Photochemical Internalization is able to enhance the
                      efficacy of Ranpirnase, a cytotoxic amphibian ribonuclease,
                      for eradication of squamous cell carcinoma of the head and
                      neck.Cell viability was measured in 8 primary human cell
                      lines of squamous cell carcinoma of the head and neck after
                      treatment with Ranpirnase and Photochemical Internalization.
                      For Photochemical Internalization the photosensitizer
                      disulfonated tetraphenyl porphine was incubated with tumor
                      cells followed by exposure to blue light (435 nm).Our study
                      demonstrates significant enhancement of antitumor activity
                      of Ranpirnase by Photochemical Internalization. Treatment
                      responses were heterogeneous between the primary cancer cell
                      lines. Combining Photochemical Internalization with
                      Ranpirnase resulted in 4.6 to 1,940-fold increased
                      cytotoxicity when compared with the ribonuclease alone (P <
                      0.05).Cytotoxicity of Ranpirnase can be markedly enhanced by
                      Photochemical Internalization in squamous cell carcinoma of
                      the head and neck.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29161778},
      url          = {https://inrepo02.dkfz.de/record/131060},
}