TY  - JOUR
AU  - Horn, Dominik
AU  - Freudlsperger, Christian
AU  - Holzinger, Dana
AU  - Kunzmann, Kevin
AU  - Plinkert, Peter
AU  - Dyckhoff, Gerhard
AU  - Hoffmann, Jürgen
AU  - Freier, Kolja
AU  - Hess, Jochen
TI  - Upregulation of pAKT(Ser473) expression in progression of HPV-positive oropharyngeal squamous cell carcinoma.
JO  - Head & neck
VL  - 39
IS  - 12
SN  - 1043-3074
CY  - New York, NY [u.a.]
PB  - Wiley Interscience
M1  - DKFZ-2017-06179
SP  - 2397 - 2405
PY  - 2017
AB  - PIK3CA alterations have been shown to be a frequent event in oropharyngeal squamous cell cancer (SCC), especially in human papillomavirus (HPV)-related tumors.Tissue microarrays (TMAs) were used to evaluate pAKT(Ser473)/(Thr308), total protein kinase B (AKT)(pan) and phosphatase and tensin homolog (PTEN) expression in primary tumors and corresponding nodal disease in oropharyngeal SCC. The HPV status was determined in regard of HPV16 DNA and RNA. Survival analysis was performed by using Kaplan-Meier curves, log-rank testing, and multivariate Cox regression analysis.HPV16 is a prognostic predictive marker for advanced oropharyngeal SCC. pAKT(Ser473) and PTEN are highly expressed in HPV-related oropharyngeal SCCs in contrast to pAKT(Thr308). The pAKT(Ser473) expression increased from primary tumors to progressive nodal disease (21.1
LB  - PUB:(DE-HGF)16
C6  - pmid:28945300
DO  - DOI:10.1002/hed.24910
UR  - https://inrepo02.dkfz.de/record/131515
ER  -