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@ARTICLE{Horn:131515,
      author       = {D. Horn and C. Freudlsperger and D. Holzinger$^*$ and K.
                      Kunzmann and P. Plinkert$^*$ and G. Dyckhoff and J. Hoffmann
                      and K. Freier and J. Hess$^*$},
      title        = {{U}pregulation of p{AKT}({S}er473) expression in
                      progression of {HPV}-positive oropharyngeal squamous cell
                      carcinoma.},
      journal      = {Head $\&$ neck},
      volume       = {39},
      number       = {12},
      issn         = {1043-3074},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley Interscience},
      reportid     = {DKFZ-2017-06179},
      pages        = {2397 - 2405},
      year         = {2017},
      abstract     = {PIK3CA alterations have been shown to be a frequent event
                      in oropharyngeal squamous cell cancer (SCC), especially in
                      human papillomavirus (HPV)-related tumors.Tissue microarrays
                      (TMAs) were used to evaluate pAKT(Ser473)/(Thr308), total
                      protein kinase B (AKT)(pan) and phosphatase and tensin
                      homolog (PTEN) expression in primary tumors and
                      corresponding nodal disease in oropharyngeal SCC. The HPV
                      status was determined in regard of HPV16 DNA and RNA.
                      Survival analysis was performed by using Kaplan-Meier
                      curves, log-rank testing, and multivariate Cox regression
                      analysis.HPV16 is a prognostic predictive marker for
                      advanced oropharyngeal SCC. pAKT(Ser473) and PTEN are highly
                      expressed in HPV-related oropharyngeal SCCs in contrast to
                      pAKT(Thr308). The pAKT(Ser473) expression increased from
                      primary tumors to progressive nodal disease $(21.1\%;$ P <
                      .011).Activation of phosphoinositide 3-kinase
                      (PI3K)/pAKT(Ser473) frequently occurs in advanced
                      HPV-positive oropharyngeal SCC and elevated pAKT(Ser473)
                      levels represent a feature during progression of
                      oropharyngeal SCC, indicating a critical role of the
                      mammalian target of rapamycin (mTOR) complex. Further
                      studies are required to evaluate specific drugs targeting
                      PI3K/AKT/mTOR in consideration of PIK3CA alterations.},
      cin          = {F020 / A102},
      ddc          = {610},
      cid          = {I:(DE-He78)F020-20160331 / I:(DE-He78)A102-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28945300},
      doi          = {10.1002/hed.24910},
      url          = {https://inrepo02.dkfz.de/record/131515},
}