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@ARTICLE{Paech:131531,
      author       = {D. Paech$^*$ and P. Schuenke$^*$ and C. Koehler and J.
                      Windschuh$^*$ and S. Mundiyanapurath and S. Bickelhaupt$^*$
                      and D. Bonekamp$^*$ and P. Bäumer$^*$ and P. Bachert$^*$
                      and M. Ladd$^*$ and M. Bendszus and W. Wick$^*$ and A.
                      Unterberg and H.-P. Schlemmer$^*$ and M. Zaiss$^*$ and A.
                      Radbruch$^*$},
      title        = {{T}1ρ-weighted {D}ynamic {G}lucose-enhanced {MR} {I}maging
                      in the {H}uman {B}rain.},
      journal      = {Radiology},
      volume       = {285},
      number       = {3},
      issn         = {1527-1315},
      address      = {Oak Brook, Ill.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2017-06195},
      pages        = {914 - 922},
      year         = {2017},
      abstract     = {Purpose To evaluate the ability to detect intracerebral
                      regions of increased glucose concentration at T1ρ-weighted
                      dynamic glucose-enhanced (DGE) magnetic resonance (MR)
                      imaging at 7.0 T. Materials and Methods This prospective
                      study was approved by the institutional review board. Nine
                      patients with newly diagnosed glioblastoma and four healthy
                      volunteers were included in this study from October 2015 to
                      July 2016. Adiabatically prepared chemical
                      exchange-sensitive spin-lock imaging was performed with a
                      7.0-T whole-body unit with a temporal resolution of
                      approximately 7 seconds, yielding the time-resolved DGE
                      contrast. T1ρ-weighted DGE MR imaging was performed with
                      injection of 100 mL of $20\%$ d-glucose via the cubital
                      vein. Glucose enhancement, given by the relative signal
                      intensity change at T1ρ-weighted MR imaging (DGEρ), was
                      quantitatively investigated in brain gray matter versus
                      white matter of healthy volunteers and in tumor tissue
                      versus normal-appearing white matter of patients with
                      glioblastoma. The median signal intensities of the assessed
                      brain regions were compared by using the Wilcoxon rank-sum
                      test. Results In healthy volunteers, the median signal
                      intensity in basal ganglia gray matter (DGEρ = $4.59\%)$
                      was significantly increased compared with that in white
                      matter tissue (DGEρ = $0.65\%)$ (P = .028). In patients,
                      the median signal intensity in the glucose-enhanced tumor
                      region as displayed on T1ρ-weighted DGE images (DGEρ =
                      $2.02\%)$ was significantly higher than that in
                      contralateral normal-appearing white matter (DGEρ =
                      $0.08\%)$ (P < .0001). Conclusion T1ρ-weighted DGE MR
                      imaging in healthy volunteers and patients with newly
                      diagnosed, untreated glioblastoma enabled visualization of
                      brain glucose physiology and pathophysiologically increased
                      glucose uptake and may have the potential to provide
                      information about glucose metabolism in tumor tissue. ©
                      RSNA, 2017 Online supplemental material is available for
                      this article.},
      keywords     = {Contrast Media (NLM Chemicals) / Glucose (NLM Chemicals)},
      cin          = {E010 / E020 / G370 / E012},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331 /
                      I:(DE-He78)G370-20160331 / I:(DE-He78)E012-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28628422},
      doi          = {10.1148/radiol.2017162351},
      url          = {https://inrepo02.dkfz.de/record/131531},
}