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@ARTICLE{Thierauf:131616,
      author       = {J. Thierauf and J. A. Veit and J. K. Lennerz and S. E.
                      Weissinger and A. Affolter and J. Döscher and C. Bergmann
                      and A. Knopf and J. Grünow$^*$ and L. Grünmüller and C.
                      Mauch and P. K. Plinkert and T. K. Hoffmann and J. Hess$^*$},
      title        = {{E}xpression of {K}allikrein-{R}elated {P}eptidase 6 in
                      {P}rimary {M}ucosal {M}alignant {M}elanoma of the {H}ead and
                      {N}eck.},
      journal      = {Head and neck pathology},
      volume       = {11},
      number       = {3},
      issn         = {1936-0568},
      address      = {[Totowa, NJ]},
      publisher    = {Humana Press},
      reportid     = {DKFZ-2017-06248},
      pages        = {314 - 320},
      year         = {2017},
      abstract     = {Mucosal melanomas of the head and neck (MMHN) are
                      aggressive tumors with poor prognosis, different opposed to
                      cutaneous melanoma. In this study, we characterized primary
                      mucosal malignant melanoma for the expression of
                      Kallikrein-related peptidase 6 (KLK6), a member of the KLK
                      family with relevance to the malignant phenotype in various
                      cancer types including cutaneous melanoma. Paraffin-embedded
                      MMHN of 22 patients were stained immunohistochemically for
                      KLK6 and results were correlated with clinical and
                      pathological data. In $77.3\%$ (17/22) of MMHN cases,
                      positive KLK6 staining was found. Staining pattern for tumor
                      cells showed a predominant cytoplasmic staining. However, in
                      six cases we also observed a prominent nuclear staining.
                      MMHN with a high KLK6 expression showed significantly better
                      outcome concerning local recurrence-free survival
                      (p = 0.013) and nuclear KLK6 staining was significantly
                      associated with the survival status (p = 0.027).
                      Overexpression of KLK6 was detected in more than $70\%$ of
                      MMHN and approximately $40\%$ of tumors showed a strong
                      expression pattern. Correlation between clinical outcome of
                      MMHN patients and overexpression of KLK6 has not been
                      addressed so far. Our data demonstrate for the first time
                      increased levels of KLK6 in MMHN and strengthen the
                      hypothesis that there might be a context-specific regulation
                      and function of KLK6 in mucosal melanoma.},
      cin          = {A102 / E210 / G405},
      ddc          = {610},
      cid          = {I:(DE-He78)A102-20160331 / I:(DE-He78)E210-20160331 /
                      I:(DE-He78)G405-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27844409},
      pmc          = {pmc:PMC5550389},
      doi          = {10.1007/s12105-016-0769-7},
      url          = {https://inrepo02.dkfz.de/record/131616},
}