%0 Journal Article
%A Vinsensia, Maria
%A Chyoke, Peter L
%A Hadaschik, Boris
%A Holland-Letz, Tim
%A Moltz, Jan
%A Kopka, Klaus
%A Rauscher, Isabel
%A Mier, Walter
%A Schwaiger, Markus
%A Haberkorn, Uwe
%A Mauer, Tobias
%A Kratochwil, Clemens
%A Eiber, Matthias
%A Giesel, Frederik
%T 68Ga-PSMA PET/CT and Volumetric Morphology of PET-Positive Lymph Nodes Stratified by Tumor Differentiation of Prostate Cancer.
%J Journal of nuclear medicine
%V 58
%N 12
%@ 2159-662X
%C New York, NY
%I Soc.
%M DKFZ-2017-06256
%P 1949 - 1955
%D 2017
%X 68Ga-prostate-specific membrane antigen (PSMA) PET/CT is a new method to detect early nodal metastases in patients with biochemical relapse of prostate cancer. In this retrospective investigation, the dimensions, volume, localization, and SUVmax of nodes identified by 68Ga-PSMA were correlated to their Gleason score (GS) at diagnosis. Methods: All PET/CT images were acquired 60 ± 10 min after intravenous injection of 68Ga-PSMA (mean dose, 176 MBq). In 147 prostate cancer patients (mean age, 68 y; range, 44-87 y) with prostate-specific antigen relapse (mean prostate-specific antigen level, 5 ng/mL; range, 0.25-294 ng/mL), 362 68Ga-PSMA PET-positive lymph nodes (LNs) were identified. These patients were classified on the basis of their histopathology at primary diagnosis into either low- (GS ≤ 6, well differentiated), intermediate- (GS = 7, moderately differentiated), or high-GS cohorts (GS ≥ 8, poorly differentiated prostate cancer). Using semiautomated LN segmentation software (Fraunhofer MEVIS), we measured node volume and short-axis dimensions (SADs) and long-axis dimensions based on CT and compared with the SUVmax Nodes demonstrating uptake of 68Ga-PSMA with an SUVmax of 2.0 or more were considered PSMA-positive, and nodes with an SAD of 8 mm or more were considered positive by morphologic criteria. Results: Mean SUVmax was 13.5 (95
%K (68Ga)Glu-urea-Lys(Ahx)-HBED-CC (NLM Chemicals)
%K Antigens, Surface (NLM Chemicals)
%K Organometallic Compounds (NLM Chemicals)
%K Radiopharmaceuticals (NLM Chemicals)
%K Glutamate Carboxypeptidase II (NLM Chemicals)
%K glutamate carboxypeptidase II, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28637799
%R 10.2967/jnumed.116.185033
%U https://inrepo02.dkfz.de/record/131624