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| Home > Publications database > 68Ga-PSMA PET/CT and Volumetric Morphology of PET-Positive Lymph Nodes Stratified by Tumor Differentiation of Prostate Cancer. > print |
| Home > Publications database > 68Ga-PSMA PET/CT and Volumetric Morphology of PET-Positive Lymph Nodes Stratified by Tumor Differentiation of Prostate Cancer. > print |
| 001 | 131624 | ||
| 005 | 20240228145610.0 | ||
| 024 | 7 | _ | |a 10.2967/jnumed.116.185033 |2 doi |
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| 024 | 7 | _ | |a 1535-5667 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-06256 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Vinsensia, Maria |b 0 |
| 245 | _ | _ | |a 68Ga-PSMA PET/CT and Volumetric Morphology of PET-Positive Lymph Nodes Stratified by Tumor Differentiation of Prostate Cancer. |
| 260 | _ | _ | |a New York, NY |c 2017 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521464649_14565 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a 68Ga-prostate-specific membrane antigen (PSMA) PET/CT is a new method to detect early nodal metastases in patients with biochemical relapse of prostate cancer. In this retrospective investigation, the dimensions, volume, localization, and SUVmax of nodes identified by 68Ga-PSMA were correlated to their Gleason score (GS) at diagnosis. Methods: All PET/CT images were acquired 60 ± 10 min after intravenous injection of 68Ga-PSMA (mean dose, 176 MBq). In 147 prostate cancer patients (mean age, 68 y; range, 44-87 y) with prostate-specific antigen relapse (mean prostate-specific antigen level, 5 ng/mL; range, 0.25-294 ng/mL), 362 68Ga-PSMA PET-positive lymph nodes (LNs) were identified. These patients were classified on the basis of their histopathology at primary diagnosis into either low- (GS ≤ 6, well differentiated), intermediate- (GS = 7, moderately differentiated), or high-GS cohorts (GS ≥ 8, poorly differentiated prostate cancer). Using semiautomated LN segmentation software (Fraunhofer MEVIS), we measured node volume and short-axis dimensions (SADs) and long-axis dimensions based on CT and compared with the SUVmax Nodes demonstrating uptake of 68Ga-PSMA with an SUVmax of 2.0 or more were considered PSMA-positive, and nodes with an SAD of 8 mm or more were considered positive by morphologic criteria. Results: Mean SUVmax was 13.5 (95% confidence interval [CI], 10.9-16.1), 12.4 (95% CI, 9.9-14.9), and 17.8 (95% CI, 15.4-20.3) within the low-, intermediate-, and high-GS groups, respectively. The morphologic assessment of the 68Ga-PSMA-positive LN demonstrated that the low-GS cohort presented with smaller 68Ga-PSMA-positive LNs (mean SAD, 7.7 mm; n = 113), followed by intermediate- (mean SAD, 9.4 mm; n = 122) and high-GS cohorts (mean SAD, 9.5 mm; n = 127). On the basis of the CT morphology criteria, only 34% of low-GS patients, 56% of intermediate-GS patients, and 53% of high-GS patients were considered CT positive. Overall, 68Ga-PSMA imaging led to a reclassification of stage in 90 patients (61%) from cN0 to cN1 over CT. Conclusion:68Ga-PSMA PET is a promising modality in biochemical recurrent prostate cancer patients for N staging. Conventional imaging underestimates LN involvement compared with PSMA molecular staging score in each GS cohort. The sensitivity of 68Ga-PSMA PET/CT enables earlier detection of subcentimeter LN metastases in the biochemical recurrence setting. |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a (68Ga)Glu-urea-Lys(Ahx)-HBED-CC |2 NLM Chemicals |
| 650 | _ | 7 | |a Antigens, Surface |2 NLM Chemicals |
| 650 | _ | 7 | |a Organometallic Compounds |2 NLM Chemicals |
| 650 | _ | 7 | |a Radiopharmaceuticals |2 NLM Chemicals |
| 650 | _ | 7 | |a Glutamate Carboxypeptidase II |0 EC 3.4.17.21 |2 NLM Chemicals |
| 650 | _ | 7 | |a glutamate carboxypeptidase II, human |0 EC 3.4.17.21 |2 NLM Chemicals |
| 700 | 1 | _ | |a Chyoke, Peter L |b 1 |
| 700 | 1 | _ | |a Hadaschik, Boris |b 2 |
| 700 | 1 | _ | |a Holland-Letz, Tim |0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |b 3 |u dkfz |
| 700 | 1 | _ | |a Moltz, Jan |b 4 |
| 700 | 1 | _ | |a Kopka, Klaus |0 P:(DE-He78)9793347ba83f527b81a22ab75af9378a |b 5 |u dkfz |
| 700 | 1 | _ | |a Rauscher, Isabel |b 6 |
| 700 | 1 | _ | |a Mier, Walter |b 7 |
| 700 | 1 | _ | |a Schwaiger, Markus |b 8 |
| 700 | 1 | _ | |a Haberkorn, Uwe |0 P:(DE-He78)13a0afba029f5f64dc18b25ef7499558 |b 9 |u dkfz |
| 700 | 1 | _ | |a Mauer, Tobias |b 10 |
| 700 | 1 | _ | |a Kratochwil, Clemens |b 11 |
| 700 | 1 | _ | |a Eiber, Matthias |b 12 |
| 700 | 1 | _ | |a Giesel, Frederik |0 P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94 |b 13 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.2967/jnumed.116.185033 |g Vol. 58, no. 12, p. 1949 - 1955 |0 PERI:(DE-600)2040222-3 |n 12 |p 1949 - 1955 |t Journal of nuclear medicine |v 58 |y 2017 |x 2159-662X |
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