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000131718 0247_ $$2doi$$a10.1002/ijc.31047
000131718 0247_ $$2pmid$$apmid:28913878
000131718 0247_ $$2ISSN$$a0020-7136
000131718 0247_ $$2ISSN$$a1097-0215
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000131718 041__ $$aeng
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000131718 1001_ $$00000-0003-3220-9944$$aCampa, Daniele$$b0
000131718 245__ $$aDo pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
000131718 260__ $$aBognor Regis$$bWiley-Liss$$c2018
000131718 3367_ $$2DRIVER$$aarticle
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000131718 520__ $$aPancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share a consistent number of epidemiologic risk factors, the aim of this study was to investigate whether specific CP risk loci also contribute to PDAC susceptibility. We selected five common SNPs (rs11988997, rs379742, rs10273639, rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium. We found a weak association between the minor allele of the PRSS1-PRSS2-rs10273639 and an increased risk of developing PDAC (ORhomozygous  = 1.19, 95% CI 1.02-1.38, p = 0.023). Additionally all the SNPs confirmed statistically significant associations with risk of developing CP, the strongest being PRSS1-PRSS2-rs10273639 (ORheterozygous  = 0.51, 95% CI 0.39-0.67, p = 1.10 × 10-6 ) and MORC4-rs 12837024 (ORhomozygous  = 2.07 (1.55-2.77, ptrend  = 0.7 × 10-11 ). Taken together, the results from our study do not support variants rs11988997, rs379742, rs10273639, rs2995271 and rs12688220 as strong predictors of PDAC risk, but further support the role of these SNPs in CP susceptibility. Our study suggests that CP and PDAC probably do not share genetic susceptibility, at least in terms of high frequency variants.
000131718 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
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000131718 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000131718 650_7 $$2NLM Chemicals$$aMORC4 protein, human
000131718 650_7 $$2NLM Chemicals$$aNuclear Proteins
000131718 650_7 $$0103964-84-7$$2NLM Chemicals$$aPRSS2 protein, human
000131718 650_7 $$09002-08-8$$2NLM Chemicals$$aTrypsinogen
000131718 650_7 $$0EC 3.4.21.4$$2NLM Chemicals$$aPRSS1 protein, human
000131718 650_7 $$0EC 3.4.21.4$$2NLM Chemicals$$aTrypsin
000131718 7001_ $$0P:(DE-HGF)0$$aPastore, Manuela$$b1
000131718 7001_ $$aCapurso, Gabriele$$b2
000131718 7001_ $$aHackert, Thilo$$b3
000131718 7001_ $$aDi Leo, Milena$$b4
000131718 7001_ $$aIzbicki, Jakob R$$b5
000131718 7001_ $$aKhaw, Kay-Tee$$b6
000131718 7001_ $$aGioffreda, Domenica$$b7
000131718 7001_ $$aKupcinskas, Juozas$$b8
000131718 7001_ $$aPasquali, Claudio$$b9
000131718 7001_ $$aMacinga, Peter$$b10
000131718 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b11
000131718 7001_ $$aStigliano, Serena$$b12
000131718 7001_ $$aPeeters, Petra H$$b13
000131718 7001_ $$aKey, Timothy J$$b14
000131718 7001_ $$aTalar-Wojnarowska, Renata$$b15
000131718 7001_ $$aVodicka, Pavel$$b16
000131718 7001_ $$aValente, Roberto$$b17
000131718 7001_ $$aVashist, Yogesh K$$b18
000131718 7001_ $$aSalvia, Roberto$$b19
000131718 7001_ $$aPapaconstantinou, Ioannis$$b20
000131718 7001_ $$aShimizu, Yasuhiro$$b21
000131718 7001_ $$aValsuani, Chiara$$b22
000131718 7001_ $$aZambon, Carlo Federico$$b23
000131718 7001_ $$aGazouli, Maria$$b24
000131718 7001_ $$aValantiene, Irena$$b25
000131718 7001_ $$aNiesen, Willem$$b26
000131718 7001_ $$aMohelnikova-Duchonova, Beatrice$$b27
000131718 7001_ $$aHara, Kazuo$$b28
000131718 7001_ $$00000-0002-4294-6799$$aSoucek, Pavel$$b29
000131718 7001_ $$aMalecka-Panas, Ewa$$b30
000131718 7001_ $$aBueno-de-Mesquita, H B As$$b31
000131718 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron Scot$$b32
000131718 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b33
000131718 7001_ $$aTavano, Francesca$$b34
000131718 7001_ $$aFogar, Paola$$b35
000131718 7001_ $$00000-0002-8023-4581$$aIto, Hidemi$$b36
000131718 7001_ $$aSperti, Cosimo$$b37
000131718 7001_ $$0P:(DE-He78)7ca7eafba864e5c3ebb7598149380452$$aButterbach, Katja$$b38
000131718 7001_ $$aLatiano, Anna$$b39
000131718 7001_ $$aAndriulli, Angelo$$b40
000131718 7001_ $$aCavestro, Giulia Martina$$b41
000131718 7001_ $$aBusch, Olivier R C$$b42
000131718 7001_ $$aDijk, Frederike$$b43
000131718 7001_ $$aGreenhalf, William$$b44
000131718 7001_ $$00000-0003-1761-6314$$aMatsuo, Keitaro$$b45
000131718 7001_ $$aLombardo, Carlo$$b46
000131718 7001_ $$aStrobel, Oliver$$b47
000131718 7001_ $$aKönig, Anna-Katharina$$b48
000131718 7001_ $$0P:(DE-He78)0a8ada1f5d2ea05fc3af10cd808bfa9a$$aCuk, Katarina$$b49
000131718 7001_ $$aStrothmann, Hendrik$$b50
000131718 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b51
000131718 7001_ $$aCantore, Maurizio$$b52
000131718 7001_ $$aMambrini, Andrea$$b53
000131718 7001_ $$aOliverius, Martin$$b54
000131718 7001_ $$aPezzilli, Raffaele$$b55
000131718 7001_ $$aLandi, Stefano$$b56
000131718 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b57$$eLast author$$udkfz
000131718 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.31047$$gVol. 142, no. 2, p. 290 - 296$$n2$$p290 - 296$$tInternational journal of cancer$$v142$$x0020-7136$$y2018
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